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GALACTOSYLCERAMIDASE
Known as:
Galactocerebrosidase
, D-Galactosyl-N-acylsphingosine galactohydrolase
, Galactosidase, Galactosylceramide
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An enzyme that hydrolyzes galactose from ceramide monohexosides. Deficiency of this enzyme may cause globoid cell leukodystrophy (LEUKODYSTROPHY…
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National Institutes of Health
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Related topics
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11 relations
GALC gene
Galactocerebrosidase, human
Globoid cell leukodystrophy
In Blood
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Narrower (1)
lactosylceramidase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Mitigation of cerebellar neuropathy in globoid cell leukodystrophy mice by AAV-mediated gene therapy.
D. Lin
,
Chung-Der Hsiao
,
+8 authors
M. Chiang
Gene
2015
Corpus ID: 32689491
2006
2006
Molecular basis of globoid cell leukodystrophy in Irish setters.
Royal A. McGraw
,
K. Paige Carmichael
The Veterinary Journal
2006
Corpus ID: 8536190
2000
2000
Deletion of exons 11–17 and novel mutations of the galactocerebrosidase gene in adult- and early-onset patients with Krabbe disease
S. Selleri
,
E. Torchiana
,
+10 authors
G. Finocchiaro
Journal of Neurology
2000
Corpus ID: 24319179
Sirs: Globoid cell leukodystrophy (GLD, or Krabbe disease) is an autosomal recessive disease that usually begins during infancy…
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1999
1999
Transduction of Cultured Oligodendrocytes from Normal and Twitcher Mice by a Retroviral Vector Containing Human Galactocerebrosidase (GALC) cDNA
E. Costantino‐Ceccarini
,
A. Luddi
,
M. Volterrani
,
M. Strazza
,
M. Rafi
,
D. Wenger
Neurochemical Research
1999
Corpus ID: 24478816
Krabbe disease or globoid cell leukodystropy is a lysosomal disorder caused by a deficiency of galactocerebrosidase (GALC…
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1998
1998
Retroviral‐mediated transfer of the galactocerebrosidase gene in neural progenitor cells
Elena Torchiana
,
Laura Lulli
,
+5 authors
G. Finocchiaro
NeuroReport
1998
Corpus ID: 7881050
GLOBOID cell leukodystrophy (GCL or Krabbe disease) is a recessive disease caused by mutations of the lysosomal enzyme…
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1991
1991
Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor.
G. S. Shukla
,
A. Shukla
,
J. Inokuchi
,
N. Radin
Biochimica et Biophysica Acta
1991
Corpus ID: 8308170
1983
1983
Deficiency of lysosomal hydrolases in apparently healthy individuals.
J. Zlotogora
,
G. Bach
American journal of medical genetics
1983
Corpus ID: 39023503
The deficiency of a lysosomal hydrolase usually results in the storage of its substrate(s) leading to various clinical…
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1981
1981
Congenital muscle fiber-type disproportion in Krabbe's leukodystrophy.
F. Dehkharghani
,
H. Sarnat
,
M. Brewster
,
S. I. Roth
Archives of Neurology
1981
Corpus ID: 364658
Progressive spasticity, blindness, loss of skills, and neuropathy developed in a 4.5-month-old boy. When examined at 13 months…
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1981
1981
Effect of suramin on the activities of degradative enzymes of sphingolipids in rats.
G. Constantopoulos
,
S. Rees
,
B. Cragg
,
J. Barranger
,
R. Brady
Research communications in chemical pathology and…
1981
Corpus ID: 12216694
Three to nine days after administration of suramin, 500 mg/kg intravenously in rats, a small amount of the drug (about 0.25…
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1977
1977
Substrate specificities of the two genetically distinct human brain β-galactosidases
Brain Research
1977
Corpus ID: 20535954
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