FAQ

GALACTOSYLCERAMIDASE

Known as: Galactocerebrosidase, D-Galactosyl-N-acylsphingosine galactohydrolase, Galactosidase, Galactosylceramide 
An enzyme that hydrolyzes galactose from ceramide monohexosides. Deficiency of this enzyme may cause globoid cell leukodystrophy (LEUKODYSTROPHY… (More)
National Institutes of Health

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Topic mentions per year

1980-2017
01219802017

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13 relations
GALC geneGalactocerebrosidase, humanGloboid cell leukodystrophyIn Blood
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lactosylceramidase

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
GALACTOSYLCERAMIDASE
physiological aspects
chemical synthesis
Globoid cell leukodystrophy
GALC gene
standards characteristics

Papers overview

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2015
2015
Preclinical characterization of DUOC-01, a cell therapy product derived from banked umbilical cord blood for use as an adjuvant to umbilical cord blood transplantation for treatment of inherited…
BACKGROUND AIMS Cord blood (CB) transplantation slows neurodegeneration during certain inherited metabolic diseases. However, the… (More)
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2015
2015
Reprint of: Preclinical characterization of DUOC-01, a cell therapy product derived from banked umbilical cord blood for use as an adjuvant to umbilical cord blood transplantation for treatment of…
BACKGROUND AIMS Cord blood (CB) transplantation slows neurodegeneration during certain inherited metabolic diseases. However, the… (More)
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2008
2008
Sustained neurological improvement following reduced-intensity conditioning allogeneic haematopoietic stem cell transplantation for late-onset Krabbe disease
Krabbe disease, or globoid cell leukodystrophy, is an autosomal recessive disease caused by a deficiency of the lysosomal enzyme… (More)
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2005
2005
Galactocerebrosidase-deficient oligodendrocytes maintain stable central myelin by exogenous replacement of the missing enzyme in mice.
Globoid cell leukodystrophy (GLD) is a lysosomal storage disease caused by genetic deficiency of galactocerebrosidase (GALC… (More)
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1995
1995
A large deletion together with a point mutation in the GALC gene is a common mutant allele in patients with infantile Krabbe disease.
Galactocerebrosidase (GALC) activity is deficient in all patients with globoid cell leukodystrophy (GLD). While most patients… (More)
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1994
1994
Purification and characterization of galactocerebrosidase from human lymphocytes.
Galactocerebrosidase was purified about 22,600-fold using several hydrophobic column and gel filtration steps with a 4.8… (More)
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1993
1993
Galactocerebrosidase from human urine: purification and partial characterization.
Galactocerebrosidase (GALC, EC 3.2.1.46) was purified from human urine by a series of hydrophobic affinity column chromatography… (More)
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1992
1992
Detection of migrated allogeneic oligodendrocytes throughout the central nervous system of the galactocerebrosidase-deficient twitcher mouse.
Galactocerebrosidase-deficient oligodendrocytes of 'twitcher' (twi/twi) mice degenerate prematurely. Transplantation of normal… (More)
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1987
1987
Hematopoietic cell transplantation in murine globoid cell leukodystrophy (the twitcher mouse): effects on levels of galactosylceramidase, psychosine, and galactocerebrosides.
Hematopoietic cell transplantation (HCT) prolongs survival in the twitcher mouse, an authentic animal model of human globoid cell… (More)
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1980
1980
The interrelations between high- and low-molecular weight forms of normal and mutant (Krabbe-disease) galactocerebrosidase.
Galactocerebrosidase (beta-d-galactosyl-N-acylsphingosine galactohydrolase; EC 3.2.1.46) activity of brain and liver preparations… (More)
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