GA-Binding Protein Transcription Factor

Known as: GA Binding Protein, Nuclear Respiratory Factor-2, nrf-2 
A heterotetrameric transcription factor composed of two distinct proteins. Its name refers to the fact it binds to DNA sequences rich in GUANINE and… (More)
National Institutes of Health

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In BloodProcess of secretionagonistsantagonists & inhibitors
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Broader (1)

Nuclear Respiratory Factors

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Highly Cited
2012
Highly Cited
2012
Brassinosteroid, gibberellin, and phytochrome impinge on a common transcription module in Arabidopsis
Brassinosteroid and gibberellin promote many similar developmental responses in plants; however, their relationship remains… (More)
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Highly Cited
2012
Highly Cited
2012
Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway
The citric acid cycle (CAC) metabolite fumarate has been proposed to be cardioprotective; however, its mechanisms of action… (More)
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Highly Cited
2009
Highly Cited
2009
Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer.
PURPOSE NF-E2-related factor 2 (Nrf2), a key transcription regulator for antioxidant and detoxification enzymes, is abundantly… (More)
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Highly Cited
2009
Highly Cited
2009
Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response.
To maintain intracellular redox homeostasis, genes encoding many antioxidants and detoxification enzymes are transcriptionally… (More)
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Highly Cited
2008
Highly Cited
2008
Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer.
The nuclear factor-erythroid 2-related factor 2 (Nrf2) plays a critical role in protecting various tissues against inflammation… (More)
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Highly Cited
2003
Highly Cited
2003
Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles.
Congestive heart failure (CHF) induces alterations in energy metabolism and mitochondrial function that span cardiac as well as… (More)
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Highly Cited
2003
Highly Cited
2003
Oxidative Stress of Nrf 2 by Chemopreventive Agents and Ubiquitination of Nrf 2 and for Stabilization Required for Keap 1-Dependent Distinct Cysteine Residues in Keap 1 Are
 
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Highly Cited
2000
Highly Cited
2000
Affinity profiles for human somatostatin receptor subtypes SST1–SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use
In vivo somatostatin receptor scintigraphy using Octreoscan is a valuable method for the visualisation of human endocrine tumours… (More)
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Highly Cited
1999
Highly Cited
1999
Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element.
The rate-limiting step in the de novo synthesis of the cellular protectant glutathione is catalyzed by gamma-glutamylcysteine… (More)
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Highly Cited
1991
Highly Cited
1991
Identification of Ets- and notch-related subunits in GA binding protein.
Recombinant cDNA clones that encode two distinct subunits of the transcription factor GA binding protein (GABP) have been… (More)
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