G2 Phase Cell Cycle Checkpoints

Known as: G2 Phase Checkpoint, G2 Phase Checkpoints, Checkpoints, G2 Phase 
CELL CYCLE regulatory signaling systems that are triggered by DNA DAMAGE or lack of nutrients during G2 PHASE. When triggered they restrain cells… (More)
National Institutes of Health

Papers overview

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Review
2012
Review
2012
Cell survival following DNA damage depends on activating checkpoints to arrest proliferation. Most cancer cells have dysregulated… (More)
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Highly Cited
2010
Highly Cited
2010
The median survival for patients with locally advanced pancreatic cancer treated with gemcitabine and radiation is approximately… (More)
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Highly Cited
2007
Highly Cited
2007
DNA double-strand break (DSB) repair and checkpoint control represent distinct mechanisms to reduce chromosomal instability… (More)
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Highly Cited
2006
Highly Cited
2006
Checkpoint adaptation was originally defined in yeast as the ability to divide despite the presence of damaged DNA. An important… (More)
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Highly Cited
2004
Highly Cited
2004
S(N)1-type alkylating agents represent an important class of chemotherapeutics, but the molecular mechanisms underlying their… (More)
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Highly Cited
1999
Highly Cited
1999
The p53 tumor suppressor controls multiple cell cycle checkpoints regulating the mammalian response to DNA damage. To identify… (More)
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Highly Cited
1998
Highly Cited
1998
M-phase-promoting factor (MPF), a complex of cdc2 and a B-type cyclin, is a key regulator of the G2/M cell cycle transition… (More)
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Highly Cited
1997
Highly Cited
1997
Human Cdc25C is a dual-specificity protein phosphatase that controls entry into mitosis by dephosphorylating the protein kinase… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Arrest of the cell cycle in G2 phase following DNA damage helps protect cell viability by allowing time for DNA repair… (More)
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Highly Cited
1992
Highly Cited
1992
We have tested mutants corresponding to 20 DNA repair genes of the fission yeast Schizosaccharomyces pombe for their ability to… (More)
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