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Activatable photosensitizers for imaging and therapy.
This work focuses on the design and implementation of Activatable Photosensitizer Design Considerations, a very simple and straightforward process that simplifies and automates the very labor-intensive and therefore time-heavy and expensive process of Activation Mechanism Selection. Expand
Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents.
The development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy. Expand
Rerouting lipoprotein nanoparticles to selected alternate receptors for the targeted delivery of cancer diagnostic and therapeutic agents.
We report that a lipoprotein-based nanoplatform generated by conjugating tumor-homing molecules to the protein components of naturally occurring lipoproteins reroutes them from their normalExpand
Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activation
This study validates the core principle of the PMB concept that selective PDT-induced cell death can be achieved by exerting precise control of the PS's ability to produce 1O2 by responding to specific cancer-associated biomarkers, and PDT selectivity will no longer depend on how selectively the PS can be delivered to cancer cells. Expand
Lipoprotein-based nanoparticles rescue the memory loss of mice with Alzheimer's disease by accelerating the clearance of amyloid-beta.
The findings here provided the direct evidence of a biomimetic nanostructure crossing the blood-brain barrier, capturing Aβ and facilitating its degradation by glial cells, indicating that ApoE3-rHDL might serve as a novel nanomedicine for disease modification in AD by accelerating Aβ clearance. Expand
Lipoprotein-Inspired Nanoparticles for Cancer Theranostics
This Account reviews the field of lipoprotein-inspired nanoparticles related to the delivery of cancer imaging and therapy agents and discusses how synthetic HDL-like nanoparticles, which do not include human or recombinant proteins, can deliver molecules directly to the cytoplasm of certain cancer cells, effectively bypassing the endosomal compartment. Expand
Advancing porphyrin's biomedical utility via supramolecular chemistry.
Porphyrins are organic heterocyclic macrocycles with photophysical properties well-suited for clinical phototherapy and cancer imaging. However, their wider application in the clinical management ofExpand
A PEGylation-Free Biomimetic Porphyrin Nanoplatform for Personalized Cancer Theranostics.
PLP offers a biomimetic theranostic nanoplatform for pretreatment stratification using PET and NIR fluorescence imaging and for further customized cancer management via imaging-guided surgery, PDT, or/and potential chemotherapy. Expand
Investigating the impact of nanoparticle size on active and passive tumor targeting efficiency.
It is demonstrated that tumor accumulation can be mediated by high nanoparticle avidity and are weakly dependent on their plasma clearance rate, and empirical models can be used to rapidly screen novel nanomaterials for relative differences in tumor targeting without the need for animal work. Expand
Overcoming obstacles in the tumor microenvironment: Recent advancements in nanoparticle delivery for cancer theranostics.
Recent advances in cancer nanomedicine exploiting both nanoparticle design and tumor microenvironment modification are highlighted; and a critical perspective on the future development of nanomedICine delivery in oncology is provided. Expand