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G2 DNA damage checkpoint

Known as: G2/M transition DNA damage checkpoint 
A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase in the cell cycle in response to DNA damage. [GOC… 
National Institutes of Health

Papers overview

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2020
2020
Enhanced UV Resistance Role of Death Domain–Associated Protein in Human MDA-MB-231 Breast Cancer Cells by Regulation of G2 DNA Damage Checkpoint
Purpose: Death domain–associated protein (DAXX) is a multifunctional nuclear protein involved in apoptosis, transcription… 
2013
2013
Dovitinib induces mitotic defects and activates the G2 DNA damage checkpoint
Dovitinib (TKI258; formerly CHIR‐258) is an orally bioavailable inhibitor of multiple receptor tyrosine kinases. Interestingly… 
2011
2011
Methods for studying the G2 DNA damage checkpoint in mammalian cells.
In response to post-replicative DNA damage, cells activate the G2 DNA damage checkpoint to ensure mitosis is not attempted until… 
2008
2008
Abnormal cytokinesis after X-irradiation in tumor cells that override the G2 DNA damage checkpoint.
X-irradiation-induced DNA damage perturbs the G(1), S, and G(2) phases of the cell cycle. The behavior of cells after they have… 
Highly Cited
2004
Highly Cited
2004
Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide.
Inhibitors of the G(2) DNA damage checkpoint can selectively sensitize cancer cells with mutated p53 to killing by DNA-damaging… 
Highly Cited
2004
Highly Cited
2004
Recovery from DNA damage checkpoint arrest by PP1‐mediated inhibition of Chk1
The G2 DNA damage checkpoint delays mitotic entry via the upregulation of Wee1 kinase and the downregulation of Cdc25 phosphatase… 
Highly Cited
2001
Highly Cited
2001
Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells
Cell cycle checkpoints are surveillance mechanisms that monitor and coordinate the order and fidelity of cell cycle events. When… 
Highly Cited
2001
Highly Cited
2001
Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine*
Cells can respond to DNA damage by activating checkpoints that delay cell cycle progression and allow time for DNA repair… 
Highly Cited
2000
Highly Cited
2000
p21 Inhibits Thr161 Phosphorylation of Cdc2 to Enforce the G2 DNA Damage Checkpoint*
The cyclin-dependent kinase inhibitor p21 is required for a sustained G2 arrest after activation of the DNA damage checkpoint… 
Highly Cited
1997
Highly Cited
1997
Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation
The G2 DNA damage checkpoint ensures maintenance of cell viability by delaying progression into mitosis in cells which have… 
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