G-quadruplex DNA formation

Known as: G quadruplex DNA formation, G quartet DNA formation, G-quartet DNA formation 
A DNA metabolic process that results in the formation of G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen… (More)
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
The disease-associated r(GGGGCC)n repeat from the C9orf72 gene forms tract length-dependent uni- and multimolecular RNA G-quadruplex structures.
Certain DNA and RNA sequences can form G-quadruplexes, which can affect promoter activity, genetic instability, RNA splicing… (More)
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2010
2010
Positive effects of ATP on G-quadruplex-hemin DNAzyme-mediated reactions.
Some G-quadruplex-hemin complexes can be used as peroxidase-mimicking DNAzymes, catalyzing H(2)O(2)-mediated reactions such as… (More)
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2007
2007
Sequence specificity of inter- and intramolecular G-quadruplex formation by human telomeric DNA.
Human telomeric DNA consists of tandem repeats of the sequence 5'-d(TTAGGG)-3'. Guanine-rich DNA, such as that seen at telomeres… (More)
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2007
2007
Circular dichroism spectra demonstrate formation of the thrombin-binding DNA aptamer G-quadruplex under stabilizing-cation-deficient conditions.
It is noteworthy that the formation of the DNA G-quadruplex is induced by factors other than stabilizing cations because this… (More)
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2007
2007
Induction of parallel human telomeric G-quadruplex structures by Sr(2+).
Human telomeric DNA forms G-quadruplex secondary structures, which can inhibit telomerase activity and are targets for anti… (More)
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Highly Cited
2005
Highly Cited
2005
Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo
Telomere end-binding proteins (TEBPs) bind to the guanine-rich overhang (G-overhang) of telomeres. Although the DNA binding… (More)
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Highly Cited
2005
Highly Cited
2005
Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure.
The human telomeric sequence d[T(2)AG(3)](4) has been demonstrated to form different types of G-quadruplex structures, depending… (More)
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Highly Cited
2003
Highly Cited
2003
The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures.
Demonstration of the existence of G-quadruplex structures in telomeres of Stylonychia macronuclei and in the promoter of c-myc in… (More)
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2002
2002
Perylene diimides with different side chains are selective in inducing different G-quadruplex DNA structures and in inhibiting telomerase.
Four N,N'-disubstituted perylene diimides, having different side chains, have been studied for their ability in inducing G… (More)
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2002
2002
The relationship between ligand aggregation and G-quadruplex DNA selectivity in a series of 3,4,9,10-perylenetetracarboxylic acid diimides.
Human telomeres are comprised of d(TTAGGG) repeats that are capable of forming G-quadruplex DNA structures. Ligands that bind to… (More)
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