Fluorofenidone
National Institutes of Health
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Interleukin (IL)‐1β plays an important role in the pathogenesis of idiopathic pulmonary fibrosis. The production of IL‐1β is…
Apoptosis is one of the most important mechanisms underlying renal tubulointerstitial fibrosis. We identified a role of protein…
Background/Aims: We evaluated the therapeutic effects of fluorofenidone (AKF-PD), a novel pyridone agent, targeting oxidative…
Signaling through the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway, especially JAK2/STAT3…
Fluorofenidone (AKF‐PD) is a novel pyridone agent. The purpose of this study is to investigate the inhibitory effects of AKF‐PD…
Cardiac myofibroblast differentiation, characterized by expression of alpha-smooth muscle actin (alpha-SMA) and fibrillar…
Background/Aims: Fluorofenidone [1-(3-fluorophenyl)-5-methyl-2-(1H)-pyridone, AKF-PD], a novel pyridone agent, showed potent…
Fluorofenidone (FD) is a novel pyridone agent with significant antifibrotic effects in vitro. The purpose of this study is to…
Aim: Fluorofenidone (1‐(3‐fluorophenyl)‐5‐methyl‐2‐(1H)‐pyridone) is a novel pyridone agent. The aim of the present study is to…
OBJECTIVES
The development of novel antifibrotic agent candidates for the treatment of diabetic nephropathy. The present study…