.......................................................................................................................................... 3 Lay Summary .............................................................................................................................. 4 Introduction ..................................................................................................................................... 5 Materials and Methods .................................................................................................................. 11 Results ........................................................................................................................................... 14 F. alocis fails to induce neutrophil respiratory burst response. ................................................ 14 Products secreted during F. alocis growth primed neutrophil respiratory burst response........ 17 F. alocis challenge neither primed nor inhibited neutrophil respiratory burst response .......... 19 Viable F. alocis, but not heat-killed bacteria, delays specific granule recruitment to bacteriacontaining phagosomes ............................................................................................................. 21 F. alocis induced secretory vesicle and specific granule exocytosis ........................................ 24 F. alocis induced minimum gelatinase granule exocytosis ...................................................... 26 F. alocis does not induce azurophil granule exocytosis ........................................................... 27 Discussion ..................................................................................................................................... 28 Conclusions and Summary ....................................................................................................... 31 Acknowledgements ................................................................................................................... 32 References ..................................................................................................................................... 33