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Nuclear Factor of Activated T-Cells Isoform c4 (NFATc4/NFAT3) as a Mediator of Antiapoptotic Transcription in NMDA Receptor-Stimulated Cortical Neurons
During cortical development, when NR2B subunit is the major component of the NMDA glutamate receptors (NMDARs), moderate NMDAR activity supports neuronal survival at least in part by regulating geneExpand
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Inhibitors of Histone Deacetylases Enhance Neurotoxicity of DNA Damage
The nonselective inhibitors of class I/II histone deacetylases (HDACs) including trichostatin A and the clinically used suberoylanilide hydroxamic acid (SAHA, vorinostat) are neuroprotective inExpand
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Depletion of procathepsin D gene expression by RNA interference – A potential therapeutic target for breast cancer
Elevated level of procathepsin D (pCD), a zymogen of lysosomal aspartic proteinase cathepsin D, is associated with highly invasive neoplasms that include breast cancer. Independent studies haveExpand
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The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells.
Expression and secretion of procathepsin D (pCD) increases proliferation, metastasis and progression of breast cancer but the structural moiety by which pCD exerts these effects is still ambiguous.Expand
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Role of activation peptide of procathepsin D in proliferation and invasion of lung cancer cells.
BACKGROUND Procathepsin D (pCD) secreted by cancer cells, increases proliferation, metastasis and progression of breast cancer, however its role in lung cancer is still unclear. The purified pCD andExpand
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Neurotoxic mechanisms of DNA damage: focus on transcriptional inhibition
J. Neurochem. (2010) 114, 1537–1549.
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Ribozyme-targeting procathepsin D and its effect on invasion and growth of breast cancer cells: an implication in breast cancer therapy.
Procathepsin D (pCD), a zymogen of lysosomal aspartic peptidase cathepsin D, overexpression is correlated with highly invasive malignancies, including breast cancer. Recently, different studies haveExpand
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Procathepsin D secreted by HaCaT keratinocyte cells - A novel regulator of keratinocyte growth.
Procathepsin D (pCD), the precursor form of lysosomal aspartic protease, is overexpressed and secreted by various carcinomas. The fact that secreted pCD plays an essential role in progression ofExpand
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Cisplatin‐mediated activation of extracellular signal‐regulated kinases 1/2 (ERK1/2) by inhibition of ERK1/2 phosphatases
The mechanism(s) underlying neurodegeneration‐associated activation of ERK1/2 remain poorly understood. We report that in cultured rat cortical neurons, whose basal ERK1/2 phosphorylation requiredExpand
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Effect of procathepsin D activation peptide on gene expression of breast cancer cells.
Overexpression of procathepsin D (pCD) is reported to occur in numerous types of cancer and is associated with increased growth and metastasis. It has been established that pCD affects multipleExpand
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