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ADAM10 (A Disintegrin and Metalloprotease Domain 10) affects the pathophysiology of various cancers, and we had shown that… Expand Abstract Context. Calcium channel blocker poisoning is a common and sometimes life-threatening ingestion. Objective. To evaluate… Expand ABSTRACT Ras proteins regulate signaling pathways important for cell growth, differentiation, and survival. Oncogenic mutant Ras… Expand The effects of fendiline on L-type Ca++ currents [ICa(L)] were investigated in rat ventricular cardiomyocytes using the patch… Expand Stimulation of soluble guanylyl cyclase in rat fetal lung fibroblasts (RFL-6 cells) was used as a sensitive assay for endothelium… Expand Fendiline is an anti-anginal agent for the treatment of coronary heart disease. Together with other diphenylalkylamines it is sub… Expand The discovery of Ca++ antagonism as a new principle of action of coronary drugs reaches back to 1964, when we reported that two… Expand Ca2+ binding to calmodulin in the pCa range 5.5-7.0 exposes hydrophobic sites that bind hydrophobic inhibitory ligands, including… Expand To determine the specificity of the previously demonstrated competition of verapamil with radioligand binding to alpha-adrenergic… Expand The effect of Ca2+ antagonist drugs on Ca2+ uptake and Na+-induced Ca2+ release by isolated rabbit heart mitochondria has been… Expand