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Fatty Acid Desaturase 1

Known as: EC1.14.19.-, Delta(5) Desaturase, Delta(5) Fatty Acid Desaturase 
Fatty acid desaturase 1 (444 aa, ~52 kDa) is encoded by the human FADS1 gene. This protein plays a role in catalyzing saturation and desaturation of… 
National Institutes of Health

Related topics

Related topics

9 relations
Enzyme GeneFADS1 geneFADS1 wt AlleleFADS2 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes
Polyunsaturated fatty acids (PUFA) correlate with risk of dyslipidemia and cardiovascular diseases. Fatty acid desaturase (FADS… 
2017
2017
Alterations in fatty acid metabolism in response to obesity surgery combined with dietary counseling
Background: The effects of obesity surgery on serum and adipose tissue fatty acid (FA) profile and FA metabolism may modify the… 
2016
2016
Knockdown of delta-5-desaturase promotes the anti-cancer activity of dihomo-γ-linolenic acid and enhances the efficacy of chemotherapy in colon cancer cells expressing COX-2.
2016
2016
Red Blood Cell Fatty Acids and Incident Diabetes Mellitus in the Women’s Health Initiative Memory Study
The relations between dietary and/or circulating levels of fatty acids and the development of type 2 diabetes is unclear… 
Highly Cited
2016
Highly Cited
2016
Longitudinal associations of serum fatty acid composition with type 2 diabetes risk and markers of insulin secretion and sensitivity in the Finnish Diabetes Prevention Study
PurposeTo examine the longitudinal associations of serum fatty acid composition with type 2 diabetes, insulin secretion and… 
Highly Cited
2015
Highly Cited
2015
Evaluation of various biomarkers as potential mediators of the association between Δ5 desaturase, Δ6 desaturase, and stearoyl-CoA desaturase activity and incident type 2 diabetes in the European…
BACKGROUND An association between desaturase activity and risk of type 2 diabetes (T2D) has been found in epidemiologic studies… 
2015
2015
Dietary n-3 Polyunsaturated Fatty Acid Intakes Modify the Effect of Genetic Variation in Fatty Acid Desaturase 1 on Coronary Artery Disease
Background Previous studies suggested that dietary fatty acids could affect blood lipids by interacting with genetic variations… 
2012
2012
Total dietary fat and fatty acid content modifies plasma phospholipid fatty acids, desaturase activity indices, and urinary prostaglandin E in women.
Highly Cited
2010
Highly Cited
2010
Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study
Delta-5 (D5D) and delta-6 (D6D) desaturases are key enzymes in PUFA metabolism. Several factors (e.g. hyperglycaemia… 
2007
2007
Essential fatty acid deficiency induces fatty acid desaturase expression in rat epididymis, but not in testis.
On the molecular level, essential fatty acid deficiency (EFAD) has been associated with induced fatty acid (FA) desaturase… 
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