FAQ

Fatty Acid Desaturase 1

Known as: EC1.14.19.-, Delta(5) Desaturase, Delta(5) Fatty Acid Desaturase 
Fatty acid desaturase 1 (444 aa, ~52 kDa) is encoded by the human FADS1 gene. This protein plays a role in catalyzing saturation and desaturation of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1985-2017
02419852017

Related topics

Related topics

9 relations
Enzyme GeneFADS1 geneFADS1 wt AlleleFADS2 gene
(More)

Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
Fatty Acid Desaturase 1
Oxidation-Reduction
fatty acid metabolism
Homo sapiens
Enzyme Gene
FADS2 gene

Papers overview

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2015
2015
Evaluation of various biomarkers as potential mediators of the association between Δ5 desaturase, Δ6 desaturase, and stearoyl-CoA desaturase activity and incident type 2 diabetes in the European…
BACKGROUND An association between desaturase activity and risk of type 2 diabetes (T2D) has been found in epidemiologic studies… (More)
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2013
2013
Indices of fatty acid desaturase activity in healthy human subjects: effects of different types of dietary fat.
Δ9-Desaturase (stearoyl-CoA desaturase 1, SCD-1) regulates the desaturation of SFA, mainly stearic and palmitic, to MUFA. Δ6… (More)
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2013
2013
Association of fatty acid composition in serum phospholipids with metabolic syndrome and arterial stiffness.
BACKGROUND AND AIM We examined the association of fatty acid (FA) composition in serum phospholipids with the features of… (More)
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2012
2012
Total dietary fat and fatty acid content modifies plasma phospholipid fatty acids, desaturase activity indices, and urinary prostaglandin E in women.
Compared with diets high in fat, low-fat diets are associated with reduced risk of cardiovascular disease. We hypothesized that a… (More)
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Highly Cited
2011
Highly Cited
2011
Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition…
BACKGROUND The long-term role of fatty acids (FAs) in the cause of diabetes remains largely unclear. OBJECTIVE We aimed to… (More)
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Highly Cited
2007
Highly Cited
2007
Fatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistance
Fatty acid desaturases introduce double bonds into growing fatty acid chains. The key desaturases in humans are Δ5-desaturase… (More)
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2007
2007
Essential fatty acid deficiency induces fatty acid desaturase expression in rat epididymis, but not in testis.
On the molecular level, essential fatty acid deficiency (EFAD) has been associated with induced fatty acid (FA) desaturase… (More)
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2006
2006
Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of D5 and D6 desaturases, SREBP-1, PPARa, and PGC-1
The purpose of this work was to study whether rat lactating mammary gland can synthesize PUFAs through the expression of D5 and… (More)
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Highly Cited
2005
Highly Cited
2005
Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men
Types of dietary fat have been related to components of the metabolic syndrome. Serum fatty acid composition mainly reflects… (More)
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Highly Cited
2002
Highly Cited
2002
Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha.
In the process of seeking sterol regulatory element-binding protein 1a (SREBP-1a) target genes, we identified and cloned a cDNA… (More)
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