Fanconi anaemia nuclear complex

Known as: FA core complex location, FA nuclear complex location, FA complex location 
A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2017
051019912017

Papers overview

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Highly Cited
2011
Highly Cited
2011
Interstrand cross-links (ICLs) block replication and transcription and thus are highly cytotoxic. In higher eukaryotes, ICLs… (More)
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Highly Cited
2010
Highly Cited
2010
DNA interstrand crosslinks (ICLs) are highly toxic because they block the progression of replisomes. The Fanconi Anemia (FA… (More)
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Highly Cited
2010
Highly Cited
2010
The Fanconi anemia (FA) pathway is responsible for interstrand crosslink repair. At the heart of this pathway is the FANCI-FAND2… (More)
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2010
2010
The Fanconi anemia (FA) pathway is activated in response to DNA damage, leading to monoubiquitination of the substrates FANCI and… (More)
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Highly Cited
2009
Highly Cited
2009
Fanconi Anemia (FA) and Bloom's Syndrome (BS) are genetic disorders characterized by overlapping phenotypes, including aberrant… (More)
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Highly Cited
2009
Highly Cited
2009
FANCM is a component of the Fanconi anemia (FA) core complex and one FA patient (EUFA867) with biallelic mutations in FANCM has… (More)
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Highly Cited
2007
Highly Cited
2007
The Fanconi anemia (FA) core complex plays a crucial role in a DNA damage response network with BRCA1 and BRCA2. How this complex… (More)
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Highly Cited
2003
Highly Cited
2003
Bloom syndrome (BS) is a genetic disorder associated with dwarfism, immunodeficiency, reduced fertility, and an elevated risk of… (More)
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2002
2002
The Fanconi anaemia (FA) nuclear complex (composed of the FA proteins A, C, G and F) is essential for protection against… (More)
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Highly Cited
2000
Highly Cited
2000
Fanconi anemia (FA) is a chromosomal instability syndrome associated with a strong predisposition to cancer, particularly acute… (More)
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