FAQ

Fanconi anaemia nuclear complex

Known as: FA core complex location, FA nuclear complex location, FA complex location 
A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2017
051019912017

Papers overview

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Highly Cited
2011
Highly Cited
2011
Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.
Interstrand cross-links (ICLs) block replication and transcription and thus are highly cytotoxic. In higher eukaryotes, ICLs… (More)
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Highly Cited
2010
Highly Cited
2010
Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2
DNA interstrand crosslinks (ICLs) are highly toxic because they block the progression of replisomes. The Fanconi Anemia (FA… (More)
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Highly Cited
2010
Highly Cited
2010
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
The Fanconi anemia (FA) pathway is responsible for interstrand crosslink repair. At the heart of this pathway is the FANCI-FAND2… (More)
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2010
2010
The structure of the catalytic subunit FANCL of the Fanconi anemia core complex
The Fanconi anemia (FA) pathway is activated in response to DNA damage, leading to monoubiquitination of the substrates FANCI and… (More)
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Highly Cited
2009
Highly Cited
2009
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
Fanconi Anemia (FA) and Bloom's Syndrome (BS) are genetic disorders characterized by overlapping phenotypes, including aberrant… (More)
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Highly Cited
2009
Highly Cited
2009
Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M.
FANCM is a component of the Fanconi anemia (FA) core complex and one FA patient (EUFA867) with biallelic mutations in FANCM has… (More)
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Highly Cited
2007
Highly Cited
2007
Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.
The Fanconi anemia (FA) core complex plays a crucial role in a DNA damage response network with BRCA1 and BRCA2. How this complex… (More)
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Highly Cited
2003
Highly Cited
2003
A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.
Bloom syndrome (BS) is a genetic disorder associated with dwarfism, immunodeficiency, reduced fertility, and an elevated risk of… (More)
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2002
2002
FANCE: the link between Fanconi anaemia complex assembly and activity.
The Fanconi anaemia (FA) nuclear complex (composed of the FA proteins A, C, G and F) is essential for protection against… (More)
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Highly Cited
2000
Highly Cited
2000
The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG.
Fanconi anemia (FA) is a chromosomal instability syndrome associated with a strong predisposition to cancer, particularly acute… (More)
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