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Familial Partial Lipodystrophy, Type 3

Known as: FPLD3, Lipodystrophy, Familial Partial, Associated With PPARg Mutations, Lipodystrophy, Familial Partial, Type 3 
This type can be caused by mutation in the gene encoding PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA.
National Institutes of Health

Related topics

Related topics

15 relations
Acanthosis NigricansAutosomal dominant inheritanceGestational DiabetesHyperglycemia
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Broader (1)

Familial partial lipodystrophy

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes
Significance Genome sequencing of individuals in the population reveals new mutations in almost every protein coding gene… Expand
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Highly Cited
2009
Highly Cited
2009
Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study
Aims/hypothesisExercise training improves glucose homeostasis, but large inter-individual differences are reported, suggesting a… Expand
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Highly Cited
2008
Highly Cited
2008
Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 With Susceptibility to Type 2 Diabetes in a Japanese Population
OBJECTIVE—Recently, several genes have been shown to be associated with an increased risk of type 2 diabetes by genome-wide… Expand
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Highly Cited
2008
Highly Cited
2008
The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies
BackgroundConsidering that a portion of the heterogeneity amongst previous replication studies may be due to a variable… Expand
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Highly Cited
2007
Highly Cited
2007
Genome-wide association with diabetes-related traits in the Framingham Heart Study
BackgroundSusceptibility to type 2 diabetes may be conferred by genetic variants having modest effects on risk. Genome-wide fixed… Expand
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Review
2005
Review
2005
Muscle triglycerides and mitochondrial function: possible mechanisms for the development of type 2 diabetes
  • Michael Roden
  • International Journal of Obesity
  • 2005
    • Corpus ID: 24427594
INTRODUCTION:Obese and type 2 diabetic (T2DM) adolescents present with reduced insulin-stimulated glucose disposal and elevated… Expand
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Highly Cited
2005
Highly Cited
2005
Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity
Aims/hypothesisMorbid obesity (BMI>40 kg/m2) affecting 0.5–5% of the adult population worldwide is a major risk factor for type 2… Expand
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2005
2005
Peroxisomal proliferator activated receptor-γ deficiency in a Canadian kindred with familial partial lipodystrophy type 3 (FPLD3)
BackgroundFamilial partial lipodystrophy (Dunnigan) type 3 (FPLD3, Mendelian Inheritance in Man [MIM] 604367) results from… Expand
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Review
2005
Review
2005
Genetic and physiological insights into the metabolic syndrome.
The metabolic syndrome (MetS) is a common phenotype that is clinically defined by threshold values applied to measures of central… Expand
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2004
2004
A single-base mutation in the peroxisome proliferator-activated receptor gamma4 promoter associated with altered in vitro expression and partial lipodystrophy.
Familial partial lipodystrophy (FPLD) results from coding sequence mutations either in LMNA, encoding nuclear lamin A/C, or in… Expand
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