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FZD4 wt Allele

Known as: Fz4, FzE4, Frizzled 4, Seven Transmembrane Spanning Receptor Gene 
Human FZD4 wild-type allele is located in the vicinity of 11q14.2 and is approximately 10 kb in length. This allele, which encodes frizzled-4 protein… 
National Institutes of Health

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Related topics

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11q14.2Angiogenic ProcessG Protein-Coupled Receptor SignalingHomo sapiens

Papers overview

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2014
2014
Wnts Are Expressed in the Spinal Cord of Adult Mice and Are Differentially Induced after Injury
Abstract The Wnt family of proteins plays key roles during central nervous system development and has been involved in several… 
2014
2014
Posterior pole retinal abnormalities in mild asymptomatic FEVR.
PURPOSE To describe the posterior retinal abnormalities in asymptomatic mild familial exudative vitreoretinopathy (FEVR… 
2014
2014
The role of the hypoxia response in shaping retinal vascular development in the absence of Norrin/Frizzled4 signaling.
PURPOSE To define the role of hypoxia and vascular endothelial growth factor (VEGF) in modifying the pattern, density, and… 
2011
2011
Novel TSPAN12 mutations in patients with familial exudative vitreoretinopathy and their associated phenotypes
Purpose Mutations in tetraspanin 12 (TSPAN12) have recently been identified as a cause of autosomal dominant familial exudative… 
Highly Cited
2007
Highly Cited
2007
Novel mutations in Norrie disease gene in Japanese patients with Norrie disease and familial exudative vitreoretinopathy.
PURPOSE To search for mutations in the Norrie disease gene (NDP) in Japanese patients with familial exudative vitreoretinopathy… 
2007
2007
Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy
Mutations in Norrin signaling genes (NDP, FZD4 and LRP5) have been found in patients with familial exudative vitreoretinopathy… 
2005
2005
Genotype-phenotype variations in five Spanish families with Norrie disease or X-linked FEVR.
PURPOSE Norrie disease (OMIM 310600) is a rare X-linked disorder characterized by congenital blindness in males. Approximately 40… 
2004
2004
Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4mutations (H69Y and C181R)
Background:Familial exudative vitreoretinopathy (FEVR) is a hereditary disorder characterized by impaired vascularization of… 
2001
2001
FZD4S, a splicing variant of frizzled-4, encodes a soluble-type positive regulator of the WNT signaling pathway.
Frizzled-1 (FZD1)-FZD10 are seven-transmembrane-type WNT receptors, and SFRP1-SFRP5 are soluble-type WNT antagonists. These… 
1983
1983
Falciform retinal fold as sign of familial exudative vitreoretinopathy.
We studied family members of 9 patients with falciform retinal fold, and found a number of cases showing features of familial… 
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