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FXN gene
Known as:
X25
, FRDA GENE
, FARR
Expand
National Institutes of Health
Create Alert
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Related topics
Related topics
5 relations
FRIEDREICH ATAXIA 1
FRIEDREICH ATAXIA WITH RETAINED REFLEXES
FXN protein, human
Friedreich Ataxia
Broader (1)
Genes
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Activation of mitochondrial energy metabolism protects against cardiac failure
T. Schulz
,
D. Westermann
,
+9 authors
M. Ristow
Aging
2010
Corpus ID: 16709280
Cardiac failure is the most prevalent cause of death at higher age, and is commonly associated with impaired energy homeostasis…
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Review
2010
Review
2010
Iron homeostasis and iron acquisition in plants: maintenance, functions and consequences.
S. Zheng
Annals of Botany
2010
Corpus ID: 16112716
Iron (Fe) is fourth most abundant element in the earth's crust and is an essential nutrient for almost all organisms. Its…
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2008
2008
Ancestral roles of eukaryotic frataxin: mitochondrial frataxin function and heterologous expression of hydrogenosomal Trichomonas homologues in trypanosomes
Shaojun Long
,
M. Jirků
,
+5 authors
J. Lukeš
Molecular Microbiology
2008
Corpus ID: 17356419
Frataxin is a small conserved mitochondrial protein; in humans, mutations affecting frataxin expression or function result in…
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2008
2008
Structural basis of the iron storage function of frataxin from single-particle reconstruction of the iron-loaded oligomer.
U. Schagerlöf
,
H. Elmlund
,
+5 authors
S. Al-Karadaghi
Biochemistry
2008
Corpus ID: 206851417
The mitochondrial protein frataxin plays a central role in mitochondrial iron homeostasis, and frataxin deficiency is responsible…
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2007
2007
Frataxin, a Conserved Mitochondrial Protein, in the Hydrogenosome of Trichomonas vaginalis
P. Doležal
,
A. Dancis
,
+4 authors
J. Tachezy
Eukaryotic Cell
2007
Corpus ID: 21638797
ABSTRACT Recent data suggest that frataxin plays a key role in eukaryote cellular iron metabolism, particularly in mitochondrial…
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Highly Cited
2005
Highly Cited
2005
Extra-mitochondrial localisation of frataxin and its association with IscU1 during enterocyte-like differentiation of the human colon adenocarcinoma cell line Caco-2
F. Acquaviva
,
I. De Biase
,
+7 authors
S. Cocozza
Journal of Cell Science
2005
Corpus ID: 6082284
Friedreich's ataxia is a recessive neurodegenerative disease due to insufficient expression of the mitochondrial protein frataxin…
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Review
2004
Review
2004
Friedreich ataxia—update on pathogenesis and possible therapies
M. Voncken
,
P. Ioannou
,
M. Delatycki
Neurogenetics
2004
Corpus ID: 5763729
Abstract.Friedreich ataxia is the most-common inherited ataxia. Since the causative genetic basis was described in 1996, much has…
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2004
2004
The factors governing the thermal stability of frataxin orthologues: how to increase a protein's stability.
S. Adinolfi
,
M. Nair
,
+4 authors
A. Pastore
Biochemistry
2004
Corpus ID: 24031127
Understanding the factors governing the thermal stability of proteins and correlating them to the sequence and structure is a…
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Review
1999
Review
1999
Secondary abnormalities of mitochondrial DNA associated with neurodegeneration.
S. Tabrizi
,
A. Schapira
Biochemical Society Symposium
1999
Corpus ID: 35985076
The central nervous system has a particularly high energy requirement, thus making it very susceptible to defects in…
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Review
1998
Review
1998
Genes involved in hereditary ataxias
T. Klockgether
,
B. Evert
Trends in Neurosciences
1998
Corpus ID: 12490107
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