• Publications
  • Influence
Draft Genome Sequence of the Sexually Transmitted Pathogen Trichomonas vaginalis
TLDR
The genome sequence of the protist Trichomonas vaginalis predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria. Expand
Evolution of the Molecular Machines for Protein Import into Mitochondria
TLDR
In creating mitochondria some 2 billion years ago, the first eukaryotes needed to establish protein import machinery in the membranes of what was a bacterial endosymbiont, but the protein translocases that drive protein import into mitochondria have no obvious counterparts in bacteria, making it likely that these machines were created de novo. Expand
Giardia mitosomes and trichomonad hydrogenosomes share a common mode of protein targeting.
TLDR
It is reported that proteins targeted into mitosomes of Giardia intestinalis have targeting signals necessary and sufficient to be recognized by the mitosomal protein import machinery, and a shared mode of protein targeting supports the hypothesis that mitosome, hydrogenosomes, and mitochondria represent different forms of the same fundamental organelle having evolved under distinct selection pressures. Expand
Trichomonas hydrogenosomes contain the NADH dehydrogenase module of mitochondrial complex I
TLDR
Recruitment of complex I subunits into a H2-producing pathway provides evidence that mitochondria and hydrogenosomes are aerobic and anaerobic homologues of the same endosymbiotically derived organelle. Expand
The Minimal Proteome in the Reduced Mitochondrion of the Parasitic Protist Giardia intestinalis
TLDR
The small proteome of the Giardia mitosome reflects the reduction in mitochondrial metabolism, which is limited to the FeS cluster assembly pathway, and a simplicity in the protein import pathway required for organelle biogenesis. Expand
A Eukaryote without a Mitochondrial Organelle
TLDR
The genome sequence of a microbial eukaryote, the oxymonad Monocercomonoides sp. Expand
The Essentials of Protein Import in the Degenerate Mitochondrion of Entamoeba histolytica
TLDR
In vitro and in vivo systems are shown that E. histolytica contains a minimalist set up of the core import components in order to accommodate a handful of mitosomal proteins, which is one of the simplest known mitochondrial compartments of all eukaryotes. Expand
Dual function of Sdh3 in the respiratory chain and TIM22 protein translocase of the mitochondrial inner membrane.
TLDR
It is concluded that the assembly of Sdh3 with different partner proteins, Sdh4 and Tim18, recruits it to two different mitochondrial membrane complexes with functions in bioenergetics and protein biogenesis, respectively. Expand
Electrospun drug loaded membranes for sublingual administration of sumatriptan and naproxen.
TLDR
Two frequently used drugs, Sumatriptan succinate, naproxen, and its salt as well as combinations of these were incorporated into nanofibrous membranes via the electrospinning process and proved very flexible and mechanically resistant. Expand
Legionella pneumophila Secretes a Mitochondrial Carrier Protein during Infection
TLDR
A novel MCF member, termed Legionella nucleotide carrier Protein (LncP), was discovered encoded in the genome of Legionella pneumophila, the causative agent of Legionnaire's disease, andstrate transport studies on purified LncP reconstituted in liposomes revealed that it catalyzes unidirectional transport and exchange of ATP transport across membranes, thereby supporting a role for LncF as an ATP transporter. Expand
...
1
2
3
4
5
...