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FTY-720

Known as: FTY 720, FTY720 
National Institutes of Health

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2 relations

Broader (2)

fingolimodfingolimod hydrochloride

Papers overview

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Highly Cited
2008
Highly Cited
2008
FTY720 ameliorates experimental autoimmune neuritis by inhibition of lymphocyte and monocyte infiltration into peripheral nerves
Review
2007
Review
2007
FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis
FTY720 (fingolimod; 2-amino-2[2-(4-octylphenyl)ethyl]-1,3-propanediol, Novartis) is the prototype of a new generation of… 
Highly Cited
2004
Highly Cited
2004
FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation.
Our aim was to study the anticancer effect of the novel immunomodulator FTY720 in vitro and in vivo by investigation of cell… 
Highly Cited
2002
Highly Cited
2002
Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: Modulation of mitogenic signaling, FAK, cell‐cycle entry and apoptosis
Despite the high frequency of prostate cancer, therapeutic options for advanced disease are limited to chemotherapy, radiation or… 
Highly Cited
2000
Highly Cited
2000
Effect of FTY720, a novel immunosuppressant, on adjuvant- and collagen-induced arthritis in rats.
Highly Cited
1999
Highly Cited
1999
Early induction of apoptosis in androgen‐independent prostate cancer cell line by FTY720 requires caspase‐3 activation
We previously reported that FTY720, a metabolite from Isaria sinclairii, induced some cancer cells to undergo apoptosis, and that… 
Highly Cited
1998
Highly Cited
1998
Immunosuppressive effects of FTY720 alone or in combination with cyclosporine and/or sirolimus.
BACKGROUND We examined the ability of FTY720, a novel immunosuppressant that prolongs the survival of allografts in experimental… 
Highly Cited
1996
Highly Cited
1996
A new immunosuppressant, FTY720, induces bcl‐2‐associated apoptotic cell death in human lymphocytes
FTY720 is a unique immunosuppressive drug produced by modification of a metabolite from Isaria sinclairii. In vitro treatment of… 
Highly Cited
1996
Highly Cited
1996
FTY720, a novel immunosuppressant possessing unique mechanisms. III. Synergistic prolongation of canine renal allograft survival in combination with cyclosporine A.
Highly Cited
1996
Highly Cited
1996
FTY720, a novel immunosuppressant possessing unique mechanisms. II. Long-term graft survival induction in rat heterotopic cardiac allografts and synergistic effect in combination with cyclosporine A.
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