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Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein.
- H. Koike, S. Tomioka, +7 authors S. Ishiura
- Chemistry, Medicine
- The Biochemical journal
- 15 October 1999
MDC9, also known as meltrin gamma, is a membrane-anchored metalloprotease. MDC9 contains several distinct protein domains: a signal sequence followed by a prodomain and a domain showing sequence… Expand
Conventional multiple or microdissection testicular sperm extraction: a comparative study.
BACKGROUND Testicular sperm extraction (TESE) with ICSI is becoming the first-line treatment for non-obstructive azoospermia (NOA). Recently, the sperm retrieval rate (SRR) by microdissection TESE… Expand
Single nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations.
- H. Tanaka, Y. Miyagawa, A. Tsujimura, K. Matsumiya, A. Okuyama, Y. Nishimune
- Biology, Medicine
- Molecular human reproduction
- 1 February 2003
Although various genetic factors have been implicated in human male infertility, the causative genes for the different types of idiopathic male infertility have not been elucidated. Protamines, which… Expand
Prediction of successful outcome of microdissection testicular sperm extraction in men with idiopathic nonobstructive azoospermia.
PURPOSE Microsurgical techniques in testicular sperm extraction can improve sperm retrieval in patients with nonobstructive azoospermia (NOA). However, spermatozoa retrieval rates have still been… Expand
Excellent Long‐term Outcome of ABO‐Incompatible Living Donor Kidney Transplantation in Japan
- K. Takahashi, K. Saito, +7 authors Y. Kamiryo
- American journal of transplantation : official…
- 1 July 2004
Owing to the severe shortage of cadaveric grafts in Japan, we have performed ABO‐incompatible living donor kidney transplantation since 1989. This study assessed short‐ and long‐term outcomes in 441… Expand
Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer.
Prostate cancer often relapses during androgen-depletion therapy, even under conditions in which a drastic reduction of circulating androgens is observed. There is some evidence that androgens remain… Expand
Modulation of androgen receptor transactivation by gelsolin: a newly identified androgen receptor coregulator.
The partial agonist effect of antiandrogens has been well documented, and such effect is amplified by derived mutant androgen receptors (ARs) in prostate cancer cells. Here we report the… Expand
Potential mechanism for the effects of dexamethasone on growth of androgen-independent prostate cancer.
- K. Nishimura, N. Nonomura, +11 authors A. Okuyama
- Biology, Medicine
- Journal of the National Cancer Institute
- 21 November 2001
BACKGROUND Dexamethasone, a synthetic glucocorticoid, has clinical benefit in patients with hormone-refractory prostate cancer (HRPC), but the mechanisms responsible for its effects are unknown. The… Expand
Combined biochemical and immunochemical comparison of peptidylarginine deiminases present in various tissues.
- K. Watanabe, K. Akiyama, K. Hikichi, R. Ohtsuka, A. Okuyama, T. Senshu
- Biology, Medicine
- Biochimica et biophysica acta
- 8 September 1988
We have performed a combined biochemical and immunochemical study on the identity of peptidylarginine deiminases (EC 22.214.171.124) present in various mammalian tissues. First, we purified… Expand
Processing of beta-dystroglycan by matrix metalloproteinase disrupts the link between the extracellular matrix and cell membrane via the dystroglycan complex.
The dystroglycan complex is a membrane-spanning complex composed of two subunits, alpha- and beta-dystroglycan. alpha-dystroglycan is a cell surface peripheral membrane protein which binds to the… Expand