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FR260330

 
National Institutes of Health

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Broader (1)

Piperidines

Papers overview

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2007
2007
New strategy for the antifibrotic therapy with oral administration of FR260330 (a selective inducible nitric oxide synthase inhibitor) in rat experimental liver cirrhosis.
Inducible nitric oxide synthase (iNOS) activity is significantly elevated in viral hepatitis, alcoholic cirrhosis, and… Expand
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2006
2006
FK330, a novel inducible nitric oxide synthase inhibitor, prevents ischemia and reperfusion injury in rat liver transplantation.
Nitric oxide (NO), produced via inducible NO synthase (iNOS), is implicated in the pathophysiology of liver ischemia/reperfusion… Expand
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2006
2006
Effect of a novel inducible nitric oxide synthase inhibitor, FR260330, in prevention of renal ischemia/reperfusion injury in vervet monkeys.
Cytotoxic nitric oxide (NO) is produced during ischemia/reperfusion (I/R) injury by the expression of inducible NO synthase (iNOS… Expand
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Highly Cited
2005
Highly Cited
2005
Nuclear factor-kappaB decoy oligodeoxynucleotides prevent acute lung injury in mice with cecal ligation and puncture-induced sepsis.
The transcription factor nuclear factor-kappaB (NF-kappaB) plays a key role in expression of many inflammatory genes responsible… Expand
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2005
2005
Pharmacological profile of FR260330, a novel orally active inducible nitric oxide synthase inhibitor.
In this study, we examined effects of a newly synthesized chemical compound, FR260330, (2E)-3-(4-chlorophenyl)-N-[(1S)-2-oxo-2… Expand
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2005
2005
Effect of a novel inducible nitric oxide synthase inhibitor in prevention of rat chronic aortic rejections.
BACKGROUND Cytotoxic nitric oxide (NO) is produced during ischemia-reperfusion injury and acute and chronic rejection in… Expand
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2005
2005
New strategy for antifibrotic therapy with FR260330 (a selective inducible nitric oxide synthase inhibitor) in rat experimental liver cirrhosis
 
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2004
2004
RENAL ISCHEMIA/REPERFUSION INJURY PREVENTED BY A NOVEL INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITOR, fr260330, IN NONHUMAN PRIMATES
 
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