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FMR1 gene

Known as: FRAXA, fragile X mental retardation 1, FRAGILE X MENTAL RETARDATION PROTEIN 
This gene may be involved in the regulation of mRNA trafficking.
National Institutes of Health

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FMR1 gene activation:NFr:Pt:Bld:Qn:MolgenFMR1 gene targeted mutation analysis:Prid:Pt:Amnio fld:Nar:MolgenFMR1 protein, humanFragile X Mental Retardation Protein

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FMR1 wt Allele

Papers overview

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2014
2014
Exploring inhibitory deficits in female premutation carriers of fragile X syndrome: Through eye movements
Highly Cited
2010
Highly Cited
2010
Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration.
Premutation CGG repeat expansions (55-200 CGG repeats; preCGG) within the fragile X mental retardation 1 (FMR1) gene give rise to… 
2010
2010
The course of cognitive‐behavioral development in children with the FMR1 mutation, Williams–Beuren syndrome, and neurofibromatosis type 1: The effect of gender
The course of cognitive‐behavioral development in children with intellectual disabilities produced by genetic disorders has only… 
Highly Cited
2007
Highly Cited
2007
Neurobiology of Disease Brain-Derived Neurotrophic Factor Rescues Synaptic Plasticity in a Mouse Model of Fragile X Syndrome
Mice lacking expression of the fragile X mental retardation 1 (Fmr1) gene have deficits in types of learning that are dependent… 
Review
2005
Review
2005
Fathoming fragile X in fruit flies.
1999
1999
Fully expanded FMR1 CGG repeats exhibit a length- and differentiation-dependent instability in cell hybrids that is independent of DNA methylation.
The fragile X syndrome is characterized at the molecular level by expansion and methylation of a CGG trinucleotide repeat located… 
Highly Cited
1998
Highly Cited
1998
Re-examination of factors associated with expansion of CGG repeats using a single nucleotide polymorphism in FMR1.
In at least 98% of fragile X syndrome cases, the disease results from expansion of the CGG repeat in the 5' end of FMR1. The use… 
Highly Cited
1996
Highly Cited
1996
FMR1 in global populations.
Fragile X syndrome, a frequent form of inherited mental retardation, results from the unstable expansion of a cryptic CGG repeat… 
Highly Cited
1996
Highly Cited
1996
The chicken FMR1 gene is highly conserved with a CCT 5'-untranslated repeat and encodes an RNA-binding protein.
The transcriptional silencing of the human gene, fragile X mental retardation 1 (FMR1), is due to abnormal methylation in… 
1994
1994
Haplotype analysis at the FRAXA locus in the Japanese population.
Fragile X syndrome, one of the most common human genetic diseases, is characterized by a unique genetic mechanism which involves… 
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