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Fragile X Mental Retardation Protein

Known as: Fragile X Mental Retardation 1 Protein, FMRP Protein, Fragile X Mental Retardation-1 Protein 
A RNA-binding protein that is found predominately in the CYTOPLASM. It helps regulate GENETIC TRANSLATION in NEURONS and is absent or under-expressed… 
National Institutes of Health

Related topics

Related topics

13 relations
FMR1 geneFMR1 wt AlleleIn BloodProcess of secretion

Narrower (3)

FMR1 protein, DrosophilaFMR1 protein, humanFmr1 protein, Xenopus

Papers overview

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Review
2015
Review
2015
The double-edged sword of long non-coding RNA: The role of human brain-specific BC200 RNA in translational control, neurodegenerative diseases, and cancer.
2013
2013
Deletion of PTEN produces deficits in conditioned fear and increases fragile X mental retardation protein.
The phosphatase and tensin homolog detected on chromosome 10 (PTEN) gene product modulates activation of the phosphatidylinositol… 
Review
2011
Review
2011
Above genetics: Lessons from cerebral development in autism
While a distinct minicolumnar phenotype seems to be an underlying factor in a significant portion of cases of autism, great… 
2008
2008
Fragile X mental retardation protein recognition of G quadruplex structure per se is sufficient for high affinity binding to RNA.
Fragile X syndrome, the most common form of inherited mental retardation is caused by the expansion of a CGG trinucleotide repeat… 
Review
2007
Review
2007
Molecular and cognitive predictors of the continuum of autistic behaviours in fragile X
2007
2007
Markers of mRNA stabilization and degradation, and RNAi within astrocytoma GW bodies
GW bodies (GWBs) are unique cytoplasmic structures that contain the mRNA binding protein GW182 and other proteins involved in… 
2002
2002
Species-specific and isoform-specific RNA binding of human and mouse fragile X mental retardation proteins.
The loss of the fragile X RNA binding protein, FMRP, causes macroorchidism and mental retardation in man. The discovery of a… 
Highly Cited
2001
Highly Cited
2001
A majority of fragile X males with methylated, full mutation alleles have significant levels of FMR1messenger RNA
FMR1 mRNA levels were determined in peripheral blood leucocytes for 48 fragile X males with methylated, full mutation alleles… 
Highly Cited
1999
Highly Cited
1999
A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein.
Silenced expression of the FMR1 gene is responsible for the fragile X syndrome. The FMR1 gene codes for an RNA binding protein… 
Review
1999
Review
1999
Molecular and cellular genetics of fragile X syndrome.
Fragile X syndrome (FraX) is one of the most prevalent genetic causes of developmental disability, representing the most frequent… 
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