FLT3 Inhibitor

Known as: Receptor-Type Tyrosine-Protein Kinase FLT3 Protein Inhibitor 
Any drug or substance that inhibits the activity of receptor-type tyrosine-protein kinase FLT3 protein.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Tyrosine kinase inhibitors (TKIs) represent transformative therapies for several malignancies. Two critical features necessary… (More)
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2014
2014
BACKGROUND FLT3-internal tandem duplication (ITD) mutations are found in approximately 30% of patients with acute myeloid… (More)
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Highly Cited
2012
Highly Cited
2012
Acquired resistance to selective FLT3 inhibitors is an emerging clinical problem in the treatment of FLT3-ITD+ acute myeloid… (More)
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Highly Cited
2011
Highly Cited
2011
We examined in vivo FLT3 inhibition in acute myeloid leukemia patients treated with chemotherapy followed by the FLT3 inhibitor… (More)
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Highly Cited
2009
Highly Cited
2009
Internal tandem duplication mutations of FLT3 (FLT3/ITD mutations) are common in acute myeloid leukemia (AML) and confer a poor… (More)
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Review
2008
Review
2008
FMS-Like-Tyrosine kinase-3 (FLT3) mutations are found in about 30% of cases of acute myeloid leukemia and confer an increased… (More)
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2007
2007
PURPOSE The aim of this study was to evaluate the antileukemia activity of a novel FLT3 kinase inhibitor, FI-700. EXPERIMENTAL… (More)
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Highly Cited
2006
Highly Cited
2006
Activating mutations of FMS-like tyrosine kinase 3 (FLT3) are present in approximately one third of patients with acute myeloid… (More)
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Highly Cited
2004
Highly Cited
2004
Patients with acute myeloid leukemia (AML) harboring internal tandem duplication mutations of the FLT3 receptor (FLT3/ITD… (More)
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2004
2004
FLT3 is constitutively activated by internal tandem duplications (ITDs) in the juxtamembrane domain or by activation loop… (More)
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