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FK778
Known as:
FK 778
, FK-778
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
Manitimus
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
Novel immunosuppression: small molecules and biologics.
J. Yabu
,
F. Vincenti
Seminars in Nephrology
2007
Corpus ID: 37564057
2007
2007
The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4+ CD25- T cells.
E. Kreijveld
,
H. Koenen
,
L. Hilbrands
,
H. van Hooff
,
I. Joosten
Blood
2007
Corpus ID: 40648698
The induction of transplantation tolerance involves a T-cell-mediated process of immune regulation. In clinical transplantation…
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2006
2006
Sirolimus and FK778: a comparison of two anti‐proliferative immunosuppressants for prevention of experimental obliterative airway disease
T. Deuse
,
S. Schrepfer
,
+4 authors
H. Reichenspurner
Transplant International
2006
Corpus ID: 24047600
This study examined the efficacies of sirolimus and the novel immunosuppressive agent FK778 to prevent obliterative airway…
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2005
2005
Down-regulation of TGF-beta and VCAM-1 is associated with successful treatment of chronic rejection in rats.
G. Crews
,
L. Erickson
,
+6 authors
Hongsi Jiang
Transplantation Proceedings
2005
Corpus ID: 23440187
2005
2005
Mechanistic Study of Malononitrileamide FK778 in Cardiac Transplantation and CMV Infection in Rats
Huasong Zeng
,
W. Waldman
,
+6 authors
James W. Williams
Transplantation
2005
Corpus ID: 38464792
Background. FK778 is a malononitrilamide, a class of immune suppressive compounds with antiviral features and experimental…
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2005
2005
Inhibition of Human Dendritic Cell Maturation and Function by the Novel Immunosuppressant FK778
M. Zeyda
,
B. Kirsch
,
+5 authors
T. Stulnig
Transplantation
2005
Corpus ID: 7657816
Background. FK778, a derivative of the active leflunomide-metabolite, A77 1726, has been shown to be a powerful immunosuppressant…
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2004
2004
The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent
T. Deuse
,
S. Schrepfer
,
H. Reichenspurner
Transplantation
2004
Corpus ID: 23973593
Objective. The synthetic malononitrilamide FK778 inhibits T- and B-cell responsiveness, phagocyte effector function, exerts…
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2003
2003
Synergistic effects of malononitrilamides (FK778, FK779) with tacrolimus (FK506) in prevention of acute heart and kidney allograft rejection and reversal of ongoing heart allograft rejection in the…
K. Bilolo
,
J. Ouyang
,
+8 authors
Huifang Chen
Transplantation
2003
Corpus ID: 33916818
Background. The effects of tacrolimus (FK506) and malononitrilamides (MNA) (FK778 and FK779) monotherapy and combination therapy…
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2003
2003
Immunosuppression with a combination of the leflunomide analog, FK778, and microemulsified cyclosporine for renal transplantation in mongrel dogs
A. Kyles
,
C. Gregory
,
+4 authors
R. Morris
Transplantation
2003
Corpus ID: 37212749
Background. The leflunomide analog, FK778, is a selective pyrimidine synthesis inhibitor. In rodent models, FK778 is efficacious…
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Highly Cited
2002
Highly Cited
2002
A novel leflunomide derivative, FK778, for immunosuppression after kidney transplantation in dogs.
M. Jin
,
Masato Nakayama
,
+7 authors
S. Todo
Surgery
2002
Corpus ID: 38905174
BACKGROUND Leflunomide and its metabolite, A77 1726, interfere with pyrimidine metabolism and exert potent immunosuppression in…
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