• Publications
  • Influence
Immunogenicity and Immunomodulatory Properties of Umbilical Cord Lining Mesenchymal Stem Cells
TLDR
ClMSCs show a more beneficial immunogeneic profile and stronger overall immunosuppressive potential than aged bmMSCs.
Hepatocyte Growth Factor or Vascular Endothelial Growth Factor Gene Transfer Maximizes Mesenchymal Stem Cell–Based Myocardial Salvage After Acute Myocardial Infarction
TLDR
Elevating the tissue levels of HGF and VEGF after acute myocardial infarction seems to be a promising reparative therapeutic approach and MSC-HGF and MSP-VEGF are a valuable source for increased cytokine production and maximize the beneficial effect of M SC-based repair strategies.
Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase.
TLDR
Investigation of whether heparin mobilizes MPO from vascular compartments in humans and whether this translates into increased vascular NO bioavailability and function adds to the growing body of evidence for a causal role of MPO in compromised vascular NO signaling in humans.
Stem cell transplantation: the lung barrier.
TLDR
It is demonstrated that cell trapping in lungs can be reduced with IV SN pretreatment, increasing MSC passage through the lung capillaries, and potentially facilitating cell access to injured organs.
Local MicroRNA Modulation Using a Novel Anti-miR-21–Eluting Stent Effectively Prevents Experimental In-Stent Restenosis
TLDR
This study demonstrates the efficacy of an anti-miR–coated stent for the reduction of ISR, compared with bare-metal stents, whereas no significant off-target effects could be observed.
Video and robotic-assisted minimally invasive mitral valve surgery: a comparison of the Port-Access and transthoracic clamp techniques.
TLDR
The MICRO technique tends to shorten the time of surgery and aortic cross-clamping and reduces perioperative costs by simplifying the operative procedure.
The value of fluorine-18 deoxyglucose positron emission tomography scans in patients with ventricular assist device specific infections†
TLDR
PET-CT scan findings showed a high specificity and positive predictive value for VAD-specific infections and may have the potential to guide the clinician in handling patients with infectious complications after VAD implantation.
Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study.
TLDR
The INSPIRE trial met its primary effectiveness and safety endpoints and further research is needed to see whether the reduced incidence of PGD3 within 72 h of a transplant might translate into earlier recovery after improved long-term recovery in the non-inferiority patients.
Gender differences and outcomes in left ventricular assist device support: The European Registry for Patients with Mechanical Circulatory Support.
TLDR
Women and men differ in perioperative hemodynamics, adverse events, and mortality after VAD implantation, and a gender-dependent association of pump thrombosis with mortality was seen.
Immunological properties of extraembryonic human mesenchymal stromal cells derived from gestational tissue.
TLDR
Comparisons of the phenotype, proliferation rate, migration, immunogenicity, and immunomodulatory capabilities of human MSCs derived from umbilical cord lining, placenta, and Wharton's jelly show CL-MSCs showed the best characteristics for cell-based strategies, as they are hypo-immunogenic and show high proliferation and migration rates.
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