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Recently, by employing intra-vital confocal microscopy, we demonstrated that platelets expose phosphatidylserine (PS) and fibrin… Expand INTRODUCTION
Blood contact with artificial surfaces of extracorporeal circulation (ECC) and hypothermia as applied in cardiac… Expand OBJECTIVE
Temporary pharmacologic inhibition of platelet function during and after cardiopulmonary bypass (CPB) (platelet… Expand OBJECTIVE
Contact between blood and the synthetic surfaces of a cardiopulmonary bypass circuit leads to platelet activation, and… Expand Antiplatelet and antithrombotic effects of FK633 (a GPIIb/IIIa antagonist) and aspirin were compared. FK633 at 0.32 mg/kg i.v. or… Expand 125I-fibrinogen bound to ADP-activated fixed platelets in a saturable manner. The Scatchard plot was curvilinear but nonlinear… Expand Previous work has shown that the type strain of Streptococcus sanguis, NCTC 7863, induces aggregation of normal platelets by a… Expand The antithrombotic and restenosis-preventing effects of FK633, an inhibitor of platelet aggregation via binding to the… Expand The anti-platelet and anti-thrombotic properties of FK633, a peptide mimetic GPIIb/IIIa antagonist were studied. In human… Expand We recently reported a novel hydrophobic descriptor for quantitative structure-activity relationship (QSAR) studies, the… Expand