FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases.
- R. Furumai, Akihisa Matsuyama, S. Horinouchi
- Biology, ChemistryCancer Research
- 1 September 2002
FK228 serves as a stable prodrug to inhibit class I enzymes and is activated by reduction after uptake into the cells and implicates its clinical usefulness for counteracting glutathione-mediated drug resistance in chemotherapy.
[A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase].
- A. Tanaka
- BiologyTanpakushitsu kakusan koso. Protein, nucleic acid…
- 1 October 2007
Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation
- Kotaro Ohnishi, Katsunori Semi, Yasuhiro Yamada
- BiologyCell
- 13 February 2014
Derivation of ground-state female ES cells maintaining gamete-derived DNA methylation
- Masaki Yagi, S. Kishigami, Yasuhiro Yamada
- BiologyNature
- 26 July 2017
The derivation conditions of female ES cells are identified that display 2i/L-ES-cell-like transcriptional signatures while preserving gamete-derived DNA methylation and autonomous developmental potential, and provide insights into the derivation offemale ES cells reminiscent of the inner cell mass of preimplantation embryos.
Selective degradation of splicing factor CAPERα by anticancer sulfonamides.
- Taisuke Uehara, Y. Minoshima, T. Owa
- Biology, ChemistryNature Chemical Biology
- 24 April 2017
These sulfonamides represent selective chemical probes for disrupting CAPERα function and designate DCAFs as promising drug targets for promoting selective protein degradation in cancer therapy.
Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency.
- Masamitsu Sone, N. Morone, T. Yamamoto
- BiologyCell Metabolism
- 2 May 2017
The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis
- K. Imamura, Y. Izumi, H. Inoue
- Biology, ChemistryScience Translational Medicine
- 24 May 2017
Analysis of ALS patient iPSC-derived motor neurons indicates that Src/c-Abl inhibitors may have potential for treating ALS, and a phenotypic screen to repurpose existing drugs using ALS motor neuron survival as readout shows that inhibitors of Src or c-ABL kinases promoted autophagy and rescued ALS motor neurons from degeneration.
The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors.
- A. Tanaka, T. Nishizaki
- Biology, ChemistryBioorganic & Medicinal Chemistry Letters
- 24 March 2003
Combination of PKCε Activation and PTP1B Inhibition Effectively Suppresses Aβ-Induced GSK-3β Activation and Tau Phosphorylation
- T. Kanno, A. Tsuchiya, A. Tanaka, T. Nishizaki
- Biology, ChemistryMolecular Neurobiology
- 1 September 2016
Combination of PKCε activation and PTP1B inhibition more sufficiently activated Akt and inactivated GSK-3β than each independent treatment, to suppress amyloid β (Aβ)-induced tau phosphorylation and ameliorate spatial learning and memory impairment in 5xFAD transgenic mice, an animal model of AD.
Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development
- Masaki Yagi, M. Kabata, Yasuhiro Yamada
- BiologyNature Communications
- 24 June 2020
A set of unique de novo DNA methylation target sites for both DNMT3 enzymes during mammalian development that overlap with hypomethylated sites in human patients are reported.
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