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FK 224

Known as: FK-224, FK224 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Cyclic Peptides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2002
2002
Substance P Induced Preprotachykinin-A mRNA, Neutral Endopeptidase mRNA and Substance P in Cultured Normal Fibroblasts
In certain skin diseases, stress can modulate the induction and/or progression of cutaneous manifestations. However, little is… 
Highly Cited
1997
Highly Cited
1997
Substance P augments fibrogenic cytokine-induced fibroblast proliferation: possible involvement of neuropeptide in tissue fibrosis.
1997
1997
Role for neurokinin-2 receptor in interleukin-5-induced airway hyperresponsiveness but not eosinophilia in guinea pigs.
In the guinea pig, interleukin-5 (IL-5) has been shown to induce airway hyperresponsiveness as well as eosinophilia, which are… 
1997
1997
Tachykinin regulation of basal synovial blood flow
Experiments were performed to investigate the role of endogenously released tachykinins in the regulation of blood flow to the… 
Highly Cited
1996
Highly Cited
1996
The effect of inhaled FK224, a tachykinin NK-1 and NK-2 receptor antagonist, on neurokinin A-induced bronchoconstriction in asthmatics.
The tachykinins substance P and neurokinin A (NKA) are present in sensory airway nerves and have been implicated in the… 
Highly Cited
1994
Highly Cited
1994
Dermatome mapping in the rat hindlimb by electrical stimulation of the spinal nerves
Highly Cited
1994
Highly Cited
1994
‘Sensory‐efferent’ neural control of mucus secretion: characterization using tachykinin receptor antagonists in ferret trachea in vitro
1 We characterized the tachykinin receptor(s) mediating ‘sensory‐efferent’ neural control of release of 35S04‐labelled… 
Highly Cited
1993
Highly Cited
1993
Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea‐pigs in vivo
1 We compared the effects of two novel tachykinin receptor antagonists, FK888 (selective at the tachykinin NK1 receptor) and… 
Highly Cited
1992
Highly Cited
1992
Protection against bradykinin-induced bronchoconstriction in asthmatic patients by neurokinin receptor antagonist
Highly Cited
1992
Highly Cited
1992
Effects of FK224, a novel compound NK1 and NK2 receptor antagonist, on airway constriction and airway edema induced by neurokinins and sensory nerve stimulation in guinea pigs.
FK224 (N-[N2-[N-[N-[N-[2,3-didehydro-N-methyl-N-[N-[3-(2- penthylphenyl)-propionyl]-L-threonyl]tyrosyl]-L-leucynyl]-D… 
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