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FGFR2 gene

Known as: FIBROBLAST GROWTH FACTOR RECEPTOR BEK, FGFR2, CEK3 
This gene plays a role in mitogenesis and differentiation and mutations in the gene are associated with craniosynostotic syndromes and bone… 
National Institutes of Health

Related topics

Related topics

19 relations
AcrocephalosyndactyliaCell Differentiation processCell Proliferation Regulatory ProcessEpithelial Cell Proliferation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
The N550K/H mutations in FGFR2 confer differential resistance to PD173074, dovitinib, and ponatinib ATP-competitive inhibitors.
We sought to identify fibroblast growth factor receptor 2 (FGFR2) kinase domain mutations that confer resistance to the pan-FGFR… 
Highly Cited
2008
Highly Cited
2008
A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis.
Highly Cited
2007
Highly Cited
2007
AZD2171 Shows Potent Antitumor Activity Against Gastric Cancer Over-Expressing Fibroblast Growth Factor Receptor 2/Keratinocyte Growth Factor Receptor
Purpose: AZD2171 is an oral, highly potent, and selective vascular endothelial growth factor signaling inhibitor that inhibits… 
Highly Cited
2003
Highly Cited
2003
Evidence for Selective Advantage of Pathogenic FGFR2 Mutations in the Male Germ Line
Observed mutation rates in humans appear higher in male than female gametes and often increase with paternal age. This bias… 
Highly Cited
2001
Highly Cited
2001
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
Apert syndrome (AS) is characterized by craniosynostosis (premature fusion of cranial sutures) and severe syndactyly of the hands… 
Highly Cited
1998
Highly Cited
1998
Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain.
Multiple human skeletal and craniosynostosis disorders, including Crouzon, Pfeiffer, Jackson-Weiss, and Apert syndromes, result… 
Highly Cited
1997
Highly Cited
1997
Fibroblast growth factor receptor 2 limits and receptor 1 accelerates tumorigenicity of prostate epithelial cells.
Progressive loss of the differentiated phenotype and communication with stroma accompanies the transition of nonmalignant rat… 
Highly Cited
1996
Highly Cited
1996
Constitutive receptor activation by Crouzon syndrome mutations in fibroblast growth factor receptor (FGFR)2 and FGFR2/Neu chimeras.
Crouzon syndrome is an autosomal dominant condition primarily characterized by craniosynostosis. This syndrome has been… 
Highly Cited
1995
Highly Cited
1995
Identical mutations in the FGFR2 gene cause both Pfeiffer and Crouzon syndrome phenotypes
Mutations in the fibroblast growth factor receptor 2 (FGFR2) gene have been identified in Crouzon syndrome, an autosomal dominant… 
Highly Cited
1994
Highly Cited
1994
Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2
Jackson-Weiss syndrome is an autosomal dominant condition characterized by craniosynostosis, foot anomalies and great phenotypic… 
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