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FGFR Inhibition
Known as:
Fibroblastic Growth Factor Receptor Inhibition
Inhibition of fibroblastic growth factor receptor signaling pathway activity to prevent tumor growth.
National Institutes of Health
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2020
2020
Abstract P3-10-06: Combination of BET and FGFR inhibition as a rational therapeutic strategy for invasive lobular breast cancer
D. O’Connor
,
L. Walsh
,
+16 authors
T. Chonghaile
2020
Corpus ID: 216379984
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer after invasive ductal carcinoma (IDC…
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2018
2018
BGJ398, A Pan-FGFR Inhibitor, Overcomes Paclitaxel Resistance in Urothelial Carcinoma with FGFR1 Overexpression
Se Hyun Kim
,
Haram Ryu
,
+13 authors
S. Rha
International Journal of Molecular Sciences
2018
Corpus ID: 53304129
Paclitaxel (PTX) is commonly used to treat urothelial carcinoma (UC) after platinum-based chemotherapy has failed. However…
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2018
2018
Abstract 4781: Changes in intracellular signaling following chronic FGFR inhibition in urothelial bladder cancer models
I. Jerchel
,
A. Kamburov
,
+6 authors
Sylvia Gruenewald
Experimental and Molecular Therapeutics
2018
Corpus ID: 81231971
Preclinical and clinical studies have validated the therapeutic potential of FGFR inhibition in urothelial bladder cancer (UBC…
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2016
2016
Abstract 1631: FGF2 activation of FGFR1 in head and neck squamous cell carcinoma is associated with more invasive disease and can be attenuated by FGFR inhibition
I. English
,
Jacqueline Martinez
,
+7 authors
E. Traer
2016
Corpus ID: 78098000
Introduction. Head and neck squamous cell carcinomas (HNSCCs) account for nearly 600,000 deaths worldwide annually and have…
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2014
2014
Abstract 1736: A novel Mer tyrosine kinase inhibitor mediates increased cell killing in combination with FGFR inhibition
T. P. Newton
,
C. Cummings
,
+8 authors
D. Graham
2014
Corpus ID: 70477490
Purpose of Study: Although therapies targeting recently identified oncogenic drivers of non-small cell lung cancer (NSCLC) are in…
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