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Treatments that use a pan-FGFR (fibroblast growth factor receptor) inhibitor plus anti–PD-1 can boost antitumor responses in… Expand Genetic alterations in the fibroblast growth factor receptors (FGFRs) have been described in multiple solid tumours including… Expand Lung squamous cell carcinoma (SqCC) is a molecularly complex and genomically unstable disease. No targeted therapy is currently… Expand Activating mutations and translocations of the FGFR3 gene are commonly seen in urothelial cell carcinoma (UCC) of the bladder and… Expand Introduction. Head and neck squamous cell carcinomas (HNSCCs) account for nearly 600,000 deaths worldwide annually and have… Expand UNLABELLED
FGFR1 and FGFR2 are amplified in many tumor types, yet what determines response to FGFR inhibition in amplified… Expand Myxoid liposarcomas account for more than one third of liposarcomas and about 10% of all adult soft tissue sarcomas. The tumors… Expand Our laboratory has previously shown that some gefitinib-insensitive head and neck squamous cell carcinoma (HNSCC) cell lines… Expand Aberrant fibroblast growth factor (FGF) and FGF receptor (FGFR) system have been associated with breast cancer. The objectives of… Expand Fibroblast growth factor 23 (FGF23) is a circulating factor secreted by osteocytes that is essential for phosphate homeostasis… Expand