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FCRL4 protein, human

Known as: FcRH4, hIFGP2, FcR-Like Protein 4 
Fc receptor-like protein 4 (515 aa, ~57 kDa) is encoded by the human FCRL4 gene. This protein may be involved in B cell-mediated immune responses.
National Institutes of Health

Related topics

Related topics

11 relations
FCRL4 geneITIMImmunoglobulin C2-set DomainIntegral Membrane Proteins

Broader (1)

Fc Receptor

Papers overview

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2020
2020
FCRL4 Is an Fc Receptor for Systemic IgA, but Not Mucosal Secretory IgA
Key Points FCRL4 recognizes systemic J chain–linked IgA. FCRL4 recognition of J chain–linked IgA can be inhibited by secretory… 
2018
2018
Evidence for B Cell Exhaustion in Chronic Graft-versus-Host Disease
Chronic graft-versus-host disease (cGvHD) remains a major complication of allogeneic hematopoietic stem cell transplantation… 
Highly Cited
2017
Highly Cited
2017
B cells expressing the IgA receptor FcRL4 participate in the autoimmune response in patients with rheumatoid arthritis
2017
2017
FcRL4 Expression Identifies a Pro-inflammatory B Cell Subset in Viremic HIV-Infected Subjects
In autoimmune diseases, toll-like receptor (TLR)-stimulated pro-inflammatory IL-6-secreting B cells exert pathogenic roles… 
2017
2017
Characterization of human FCRL4-positive B cells
FCRL4 is an immunoregulatory receptor that belongs to the Fc receptor-like (FCRL) family. In healthy individuals, FCRL4 is… 
2015
2015
Involvement of the HCK and FGR src-Family Kinases in FCRL4-Mediated Immune Regulation
FCRL4 is an immunoregulatory receptor expressed by a subpopulation of memory B cells. These tissue-based cells express increased… 
Highly Cited
2013
Highly Cited
2013
HIV-1 gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression
The humoral immune response after acute infection with HIV-1 is delayed and ineffective. The HIV-1 envelope protein gp120 binds… 
2013
2013
Rituximab Provides Steroid-Sparing Therapy in New-Onset Chronic Graft-Versus-Host Disease
2008
2008
Fc receptor‐like 1–5 molecules are similarly expressed in progressive and indolent clinical subtypes of B‐cell chronic lymphocytic leukemia
Fc receptor‐like (FCRL) 1–5 molecules are exclusively expressed in B‐cells and have recently been considered as potential targets… 
2008
2008
A direct antigen-binding assay for detection of antibodies against native epitopes using alkaline phosphatase-tagged proteins.
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