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FCGRT gene

Known as: Fc fragment of IgG receptor and transporter, Fc FRAGMENT OF IgG, RECEPTOR TRANSPORTER, ALPHA, IMMUNOGLOBULIN RECEPTOR, INTESTINAL, HEAVY CHAIN 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Genes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Transepithelial Transport of Fc-Targeted Nanoparticles by the Neonatal Fc Receptor for Oral Delivery
Nanoparticles targeted to the neonatal Fc receptor cross the intestinal epithelium and reach systemic circulation after oral… 
Highly Cited
2011
Highly Cited
2011
Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies.
Highly Cited
2009
Highly Cited
2009
Engineering Human IgG1 Affinity to Human Neonatal Fc Receptor: Impact of Affinity Improvement on Pharmacokinetics in Primates
The pH-dependent binding of Igs to the neonatal FcR (FcRn) plays a critical role in the in vivo homeostasis of IgGs. Modulating… 
Review
2006
Review
2006
Perspective-- FcRn transports albumin: relevance to immunology and medicine.
Highly Cited
2005
Highly Cited
2005
Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases.
Numerous mechanisms of action have been proposed for intravenous Ig (IVIG). In this study, we used IgG passive transfer murine… 
Highly Cited
2004
Highly Cited
2004
Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway.
Administration of therapeutic proteins by methods other than injection is limited, in part, by inefficient penetration of… 
Highly Cited
1999
Highly Cited
1999
Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line.
The MHC class I-related Fc receptor, FcRn, mediates the intestinal absorption of maternal IgG in neonatal rodents and the… 
Highly Cited
1998
Highly Cited
1998
Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice.
Our recent data indicate that the MHC class I-related receptor, FcRn, plays a role in regulating serum IgG levels, in addition to… 
Highly Cited
1997
Highly Cited
1997
Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells
Maternal IgG is transferred to the suckling mouse and rat through a major histocompatibility complex (MHC) class I‐related Fc… 
Highly Cited
1996
Highly Cited
1996
Increased clearance of IgG in mice that lack β2‐microglobulin: possible protective role of FcRn
The mechanisms that regulate immunoglobulin G (IgG) catabolism are little understood. We have previously found unusually low IgG… 
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