• Publications
  • Influence
Heterogeneity of monoclonal antibodies.
Heterogeneity of monoclonal antibodies is common due to the various modifications introduced over the lifespan of the molecules from the point of synthesis to the point of complete clearance from theExpand
  • 340
  • 11
Cellular particle swarm optimization
This paper proposes a cellular particle swarm optimization (CPSO), hybridizing cellular automata (CA) and particle swarm optimization (PSO) for function optimization. In the proposed CPSO, aExpand
  • 152
  • 10
  • PDF
Disulfide bond structures of IgG molecules
The disulfide bond structures established decades ago for immunoglobulins have been challenged by findings from extensive characterization of recombinant and human monoclonal IgG antibodies.Expand
  • 242
  • 7
Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies
The existence of multiple variants with differences in either charge, molecular weight or other properties is a common feature of monoclonal antibodies. These charge variants are generally referredExpand
  • 111
  • 6
MiR-138 Inhibits Tumor Growth Through Repression of EZH2 in Non-Small Cell Lung Cancer
Background/Aims: MicroRNAs (miRNAs) play important roles in tumorigenesis. We investigated the roles and mechanisms of miR-138 in human non-small cell lung cancer (NSCLC). Methods: The expression ofExpand
  • 110
  • 6
Comparison of methionine oxidation in thermal stability and chemically stressed samples of a fully human monoclonal antibody.
Methionine (Met) oxidation is a major degradation pathway of protein therapeutics. Met oxidation of a fully human recombinant monoclonal antibody was investigated under both chemically stressedExpand
  • 144
  • 4
Kinetic differences between the isoforms of glutamate decarboxylase: implications for the regulation of GABA synthesis
Glutamate decarboxylase (GAD) exists as two isoforms, GAD65 and GAD67. GAD activity is regulated by a cycle of activation and inactivation determined by the binding and release of its co‐factor,Expand
  • 105
  • 4
Determination of amino acids in food and feed by derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate and reversed-phase liquid chromatographic separation
A study of a new amino acid analysis method using 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate as a precolumn derivatization reagent for the analysis of food and feed is described. All aminoExpand
  • 89
  • 4
A hybrid particle swarm optimization with estimation of distribution algorithm for solving permutation flowshop scheduling problem
In this paper we propose PSO-EDA, a hybrid particle swarm optimization (PSO) with estimation of distribution algorithm (EDA) to solve permutation flowshop scheduling problem (PFSP). PFSP is anExpand
  • 70
  • 4
A Discrete Electromagnetism-Like Mechanism Algorithm for Solving Distributed Permutation Flowshop Scheduling Problem
A distributed permutation flow shop scheduling problem (DPFSP) is an NP-hard problem recently put forward in shop scheduling sphere. Exact algorithms for a DPFSP’s solution can be extremelyExpand
  • 29
  • 4