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FCE-28068
Known as:
FCE28068
National Institutes of Health
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2013
2013
Validation of tumour models for use in anticancer nanomedicine evaluation: the EPR effect and cathepsin B-mediated drug release rate
R. Duncan
,
Yee-Nee Sat-Klopsch
,
A. Burger
,
M. Bibby
,
H. Fiebig
,
E. Sausville
Cancer Chemotherapy and Pharmacology
2013
Corpus ID: 11284381
PurposeIntravenously (i.v.) administered nanomedicines have the potential for tumour targeting due to the enhanced permeability…
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Highly Cited
2009
Highly Cited
2009
Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer.
L. Seymour
,
D. Ferry
,
+16 authors
J. Cassidy
International journal of oncology
2009
Corpus ID: 18838244
Phase I studies of [N-(2-hydroxypropyl)methacrylamide] (HPMA) copolymer-doxorubicin previously showed signs of activity coupled…
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Review
2009
Review
2009
Clinical experience with anthracycline antibiotics-HPMA copolymer-human immunoglobulin conjugates.
B. Říhová
Advanced drug delivery reviews
2009
Corpus ID: 20423172
Highly Cited
2007
Highly Cited
2007
Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells.
F. Greco
,
M. Vicent
,
+4 authors
R. Duncan
Journal of controlled release : official journal…
2007
Corpus ID: 25819913
2007
2007
Using small-angle neutron scattering to study the solution conformation of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates.
A. Paul
,
M. Vicent
,
R. Duncan
Biomacromolecules
2007
Corpus ID: 46688529
Our past research developed two N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-doxorubicin (Dox) conjugates that became the…
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Review
2005
Review
2005
Polymer-drug conjugates: towards a novel approach for the treatment of endrocine-related cancer.
R. Duncan
,
M. Vicent
,
F. Greco
,
R. Nicholson
Endocrine-related cancer
2005
Corpus ID: 33315378
The last decade has seen successful clinical application of polymer-protein conjugates (e.g. Oncaspar, Neulasta) and promising…
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Highly Cited
2001
Highly Cited
2001
Polymer-drug conjugates, PDEPT and PELT: basic principles for design and transfer from the laboratory to clinic.
R. Duncan
,
S. Gac-Breton
,
+4 authors
F. Searle
Journal of controlled release : official journal…
2001
Corpus ID: 46039465
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