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The dawning era of polymer therapeutics
- R. Duncan
- Biology, ChemistryNature reviews. Drug discovery
- 1 May 2003
The successful clinical application of polymer–protein conjugates, and promising clinical results arising from trials with polymer–anticancer-drug conjugate, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age.
Polymer conjugates as anticancer nanomedicines
- R. Duncan
- Biology, ChemistryNature Reviews. Cancer
- 1 September 2006
There is growing optimism that ever more sophisticated polymer-based vectors will be a signficant addition to the armoury currently used for cancer therapy.
Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo.
Dendrimer biocompatibility and toxicity.
Nanomedicine(s) under the microscope.
Both nanomedicines in clinical use and emerging nanosized drugs, drug delivery systems, imaging agents, and theranostics with unique properties that promise much for the future are reviewed.
Early Phase Tumor Accumulation of Macromolecules: A Great Difference in Clearance Rate between Tumor and Normal Tissues
The results suggest the “EPR effect” in solid tumor primarily arises from in the difference in clearance rate between the solid tumor and the normal tissues after initial penetration of the polymers into these tissues.
Endocytosis and intracellular trafficking as gateways for nanomedicine delivery: opportunities and challenges.
The endomembrane trafficking pathways are overviewed, the methods used to determine and quantitate the intracellular fate of nanomedicines are discussed, and the current status of lysosomotropic and endOSomotropic delivery is reviewed.
Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation
It is concluded that synthetically engineered macromolecules such as the dendrimers described here can be tailored to have defined immuno-modulatory and antiangiogenic properties, and they can be used synergistically to prevent scar tissue formation.
Anionic PAMAM Dendrimers Rapidly Cross Adult Rat Intestine In Vitro: A Potential Oral Delivery System?
- R. Wiwattanapatapee, B. Carreño-Gómez, N. Malik, R. Duncan
- Biology, ChemistryPharmaceutical Research
- 1 August 2000
As the anionic PAMAM dendrimers displayed serosal transfer rates that were faster than observed for other syntheticand natural macromolecules (including tomato lectin) studied in the evertedsac system, these interesting nanoscale structures may have potential for further development as oral drug delivery systems.
Phase I Clinical and Pharmacokinetic Study of PK1 [N-(2-Hydroxypropyl)methacrylamide Copolymer Doxorubicin]: First Member of a New Class of Chemotherapeutic Agents—Drug-Polymer Conjugates
PK1 comprises doxorubicin covalently bound to N -(2-hydroxypropyl)methacrylamide copolymer by a peptidyl linker. Following cellular uptake via pinocytosis, the linker is cleaved by lysosomal enzymes,…