Skip to search formSkip to main contentSkip to account menu

F8 wt Allele

Known as: DXS1253E, AHF, F8C 
Human F8 wild-type allele is located within Xq28 and is approximately 548 kb in length. This allele, which encodes coagulation factor VIII protein… 
National Institutes of Health

Related topics

Related topics

11 relations
Antihemophilic Factor, Human RecombinantBlood coagulationCalcium BindingFactor VIII

Broader (1)

F8 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Next generation FIX muteins with FVIII‐independent activity for alternative treatment of hemophilia A
FVIII neutralizing antibodies are the main complication of substitution therapy in hemophilia A (HA); auto‐antibodies against… 
2012
2012
Successful eradication of a FVIII inhibitor in a 60-year-old patient with mild haemophilia A using single-agent prednisolone
Summary Background Development of FVIII inhibitors represents a major challenge in patients with mild haemophilia A (HA), because… 
2011
2011
Pharmacokinetics of VWF/FVIII concentrates is a very intricate matter
Pharmacokinetic (PK) evaluation of clotting factor concentrates has since 1988 been a recommended procedure to evaluate not only… 
2010
2010
Stable High Level Coagulation Factor VIII Expression In Vivo Following Gene Transfer Using a Novel Expression Cassette Encoding a More Potent FVIII Variant
Abstract 250 Hemophilia A (HA, or clotting factor VIII deficiency), the commonest inherited bleeding disorder, is a good model… 
2004
2004
Mapping the δ-aminolaevulinic acid dehydrase and porphobilinogen deaminase loci in Bacillus subtilis
SummaryTwo genes (hemB, hemC) taking part in the porphyrin biosynthesis of Bacillus subtilis were mapped. The gene hemB… 
Highly Cited
1996
Highly Cited
1996
High incidence of anti‐FVIII antibodies against non‐coagulant epitopes in haemophilia A patients: a possible role for the half‐life of transfused FVIII
The occurrence of antibodies (Abs) capable of inhibiting factor VIII (FVIII) coagulant activity is a severe complication in… 
1991
1991
Oxygen tension regulated expression of the hemA gene of Rhodobacter capsulatus
The promoter of the Rhodobacter capsulatus hemA gene, coding for the enzyme δ-aminolevulinic acid synthase (ALAS), was identified… 
1989
1989
Toward a physical map of the Xq28 region in man: linking color vision, G6PD, and coagulation factor VIII genes to an X-Y homology region.
1989
1989
A new polymorphic marker very closely linked to DXS52 in the q28 region of the human X chromosome
SummaryWe have isolated an X chromosome probe, St35.691 (DXS305), which detects two RFLPs with TaqI and PstI, whose combined… 
1987
1987
Recombination between the factor VIII gene and the DXS52 locus gives the most probable genetic order as centromere-fra(X)-DXS15-DXS52-F8C-telomere.
The linkage relationship between the factor VIII gene (F8C) and the DXS52 locus was examined in 8 families. Two recombinations… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)