F8, EX4-10DEL
National Institutes of Health
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Targeting the FATP4 transporter is an effective way to transport peptides and enhance oral bioavailability of peptide drugs. Low…
We previously showed that tumor necrosis factor-alpha (TNF) produced by renal epithelial cells inhibits NKCC2 activity as part of…
The present study investigated the interaction of hypothalamic arcuate nucleus (ArcN) ghrelin and glucagon-like peptide-1 (GLP-1…
Two-pore domain potassium (K2P) channels modulate neuronal excitability throughout the entire CNS. The stretch-activated channel…
− Albumin-modification has been viewed as one of the most effective ways of extending the short in vivo lifetimes of peptide…
SUMMARY Exendin-4 (Ex4) is viewed as a potent therapeutic peptide for type 2 diabetics, but its short circulating life (4-6 h…
SUMMARY Exendin 4 (Ex4, subsequently renamed exenatide) has a potent efficacy for the treatment of type 2 diabetes under the…