Semantic Scholar uses AI to extract papers important to this topic.
While the majority of topoisomerase (topo) inhibitors show selectivity against either topo I or topo II, a small class of… Expand F 11782 is a novel epipodophyllotoxin that targets eukaryotic topoisomerases and inhibits enzyme binding to DNA. While F 11782… Expand F 11782 (2",3"-bis-pentafluorophenoxyacetyl-4",6"ethylidene-beta-D-glucoside of 4'-phosphate-4'-dimethylepipodophyllotoxin-2N… Expand F 11782, or 2',3'-bis-pentafluorophenoxyacetyl-4',6'-ethylidene-beta-D-glucoside of 4'-phosphate-4'-dimethylepipodophyllotoxin 2… Expand DNA damage induced in V79 cells by F 11782, or 2″,3″-bis pentafluorophenoxyacetyl-4′, 6′-ethylidene-β-D glucoside of 4′-phosphate… Expand F 11782, a novel epipodophylloid, proved a potent inhibitor of the catalytic activities of both topoisomerases I and II. Unlike… Expand F 11782 is a novel inhibitor of topoisomerases I and II, with an original mechanism of action (Perrin et al, 2000). This study… Expand F 11782, or 2", 3"-bis pentafluorophenoxyacetyl-4',6'-ethylidene-beta-D glucoside of 4'-phosphate-4'-dimethylepipodophyllotoxin… Expand No genuinely new targets or drugs were disclosed; instead, data about known therapeutic approaches and compounds were… Expand