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The chemistry of wine polyphenolic C-glycosidic ellagitannins targeting human topoisomerase II.
Polyphenolic nonahydroxyterphenoyl-containing C-glycosidic oak ellagitannins are found in wine as a result of the aging of this beverage in oak-made barrels. Once in the slightly acidic wine (pH… Expand
S100-B protein as a screening tool for the early assessment of minor head injury.
STUDY OBJECTIVE A computed tomography (CT) scan has high sensitivity in detecting intracranial injury in patients with minor head injury but is costly, exposes patients to high radiation doses, and… Expand
From old alkylating agents to new minor groove binders.
Alkylating agents represent the oldest class of anticancer agents with the approval of mechloretamine by the FDA in 1949. Even though their clinical use is far beyond the use of new targeted… Expand
Incorporation and metabolism of exogenous fatty acids by cultured normal and tumoral glial cells.
We have investigated the transformation of exogenous radioactive free fatty acids by cultured glial cells and their incorporation into complex lipids. The cells were either tumor lines (C6 and NN) or… Expand
Determinants of the cytotoxicity of irinotecan in two human colorectal tumor cell lines
- V. Pavillard, Cécile Agostini, S. Richard, V. Charasson, D. Montaudon, J. Robert
- Biology, Medicine
- Cancer Chemotherapy and Pharmacology
- 30 January 2002
Abstract.Purpose: Irinotecan is a drug of the camptothecin family that has proven activity in advanced colon cancer, with about 20% responses in untreated as well as in 5-fluorouracil-resistant… Expand
Synthesis and antiproliferative activity of aryl- and heteroaryl-hydrazones derived from xanthone carbaldehydes.
- M. Varache-Lembège, S. Moreau, Stéphane Larrouture, D. Montaudon, J. Robert, A. Nuhrich
- Chemistry, Medicine
- European journal of medicinal chemistry
- 1 June 2008
In order to explore the antiproliferative effect associated with the xanthone framework, several arylhydrazonomethyl derivatives were synthesized from various isomeric 1,3-dihydroxyxanthone… Expand
C-reactive protein and procalcitonin as markers of mortality in hemodialysis patients: a 2-year prospective study.
- P. Chauveau, C. Level, +5 authors C. Combe
- Journal of renal nutrition : the official journal…
- 1 April 2003
OBJECTIVE We have previously shown in a transversal study that PCT combined to CRP is associated to an altered nutritional status in hemodialysis patients. In a 2-year prospective study, we have… Expand
Impact of high-flux/high-efficiency dialysis on folate and homocysteine metabolism.
High-flux/high-efficiency (HF/HE) dialysis may have detrimental effects on micro-nutrients and water-soluble vitamins, such as vitamin B6, whose levels are lowered. Folate deficiency may increase… Expand
Procalcitonin: a new marker of inflammation in haemodialysis patients?
- C. Level, P. Chauveau, +5 authors C. Combe
- Nephrology, dialysis, transplantation : official…
- 1 April 2002
BACKGROUND Although procalcitonin (PCT) has been described as a new marker of infection and inflammation, it has not been extensively studied in dialysis patients. METHODS We measured plasma PCT… Expand
Inhibition of Topoisomerase I Cleavage Activity by Thiol-reactive Compounds
- D. Montaudon, Komaraiah Palle, +5 authors P. Pourquier
- Chemistry, Medicine
- Journal of Biological Chemistry
- 11 May 2007
DNA topoisomerase I (Top1) is a nuclear enzyme that plays a crucial role in the removal of DNA supercoiling associated with replication and transcription. It is also the target of the anticancer… Expand