Ephrin Type-B Receptor 4, human

Known as: Ephrin Type-B Receptor 4, Tyrosine-Protein Kinase Receptor HTK, Tyrosine-Protein Kinase TYRO11 
Ephrin type-B receptor 4 (987 aa, ~108 kDa) is encoded by the human EPHB4 gene. This protein plays a role in ephrin-B binding, tyrosine… (More)
National Institutes of Health

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Angiogenic ProcessAxon GuidanceCell Differentiation processCell Proliferation
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Papers overview

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Highly Cited
2012
Highly Cited
2012
Preeclampsia up-regulates angiogenesis-associated microRNA (i.e., miR-17, -20a, and -20b) that target ephrin-B2 and EPHB4 in human placenta.
CONTEXT Placental angiogenesis contributes to the pathogenesis of preeclampsia (PE) that affects 5-8% of all human pregnancies… (More)
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2010
2010
Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia.
Eph receptors and their ephrin ligands are involved in normal hematopoietic development and tumorigenesis. Using methylated CpG… (More)
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Highly Cited
2010
Highly Cited
2010
Subcellular profiling reveals distinct and developmentally regulated repertoire of growth cone mRNAs.
Cue-directed axon guidance depends partly on local translation in growth cones. Many mRNA transcripts are known to reside in… (More)
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Highly Cited
2006
Highly Cited
2006
The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl–Crk pathway
Recent evidence supports a role for EphB receptor tyrosine kinases as tumour suppressors in colorectal and prostate cancer… (More)
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Highly Cited
2005
Highly Cited
2005
Mice null for Frizzled4 (Fzd4-/-) are infertile and exhibit impaired corpora lutea formation and function.
Previous studies showed that transcripts encoding specific Wnt ligands and Frizzled receptors including Wnt4, Frizzled1 (Fzd1… (More)
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Highly Cited
2004
Highly Cited
2004
Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth.
Receptor tyrosine kinases of the Eph family are up-regulated in different types of cancer. EphB4 and its ligand ephrin-B2 have… (More)
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Highly Cited
2004
Highly Cited
2004
Identification of genes associated with tumorigenesis and metastatic potential of hypopharyngeal cancer by microarray analysis
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer among men in the developed world. There is a need… (More)
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Highly Cited
2001
Highly Cited
2001
Gridlock signalling pathway fashions the first embryonic artery
Arteries and veins are morphologically, functionally and molecularly very different, but how this distinction is established… (More)
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2001
2001
Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2(+) endothelial cells.
Ephrin-B2 is a transmembrane ligand that is specifically expressed on arterial endothelial cells (ECs) and surrounding cells and… (More)
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1999
1999
Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma.
The EPH family is the largest subfamily of receptor protein tyrosine kinases, consisting of the EPHA and EPHB subgroups. Ephrin… (More)
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