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Endothia aspartic proteinase

Known as: endothiapepsin 
National Institutes of Health

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Broader (1)

Aspartic Acid Endopeptidases

Papers overview

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Highly Cited
2007
Highly Cited
2007
Discovery of a novel warhead against beta-secretase through fragment-based lead generation.
Fragment-based lead generation was applied to find novel small-molecule inhibitors of beta-secretase (BACE-1), a key target for… 
Highly Cited
1995
Highly Cited
1995
Thermodynamic mapping of the inhibitor site of the aspartic protease endothiapepsin.
The discovery that the protease from the human immunodeficiency virus (HIV) belongs to the aspartic protease family has generated… 
Highly Cited
1994
Highly Cited
1994
X-ray analyses of aspartic proteinases. The three-dimensional structure at 2.1 A resolution of endothiapepsin.
Highly Cited
1992
Highly Cited
1992
Direct observation by X‐ray analysis of the tetrahedral “intermediate” of aspartic proteinases
We report the X‐ray analysis at 2.0 Å resolution for crystals of the aspartic proteinase endothiapepsin (EC 3.4.23.6) complexed… 
Highly Cited
1991
Highly Cited
1991
The active site of aspartic proteinases
Highly Cited
1990
Highly Cited
1990
Revised 2.3 Å structure of porcine pepsin: Evidence for a flexible subdomain
A revised three‐dimensional crystal structure of ethanol‐inhibited porcine pepsin refined to an R‐factor of 0.171 at 2.3… 
Review
1989
Review
1989
Retroviral proteases: First glimpses at the anatomy of a processing machine
Highly Cited
1989
Highly Cited
1989
High‐resolution X‐ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the…
The conformation of the synthetic renin inhibitor CP‐69,799, bound to the active site of the fungal aspartic proteinase… 
Highly Cited
1987
Highly Cited
1987
The structure of a synthetic pepsin inhibitor complexed with endothiapepsin.
The conformation of a synthetic polypeptide inhibitor, bound to the active site of the fungal aspartic proteinase endothiapepsin… 
Highly Cited
1987
Highly Cited
1987
High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes
Inhibitors of the conversion of angiotensinogen to the vasoconstrictor angiotensin II have considerable value as antihypertensive… 
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