Edeine

The hepatitis C virus (HCV) genome contains an internal ribosome entry site (IRES) followed by a large open reading frame coding… Expand

The crystal structures of the universal translation-initiation inhibitors edeine and pactamycin bound to ribosomal 30S subunit… Expand

The small ribosomal subunit is responsible for the decoding of genetic information and plays a key role in the initiation of… Expand

We have studied the interactions of the antibiotics apramycin, kasugamycin, myomycin, neamine and pactamycin with 16S rRNA by… Expand

Chemical footprinting shows that several classes of antibiotics (streptomycin, tetracycline, spectinomycin, edeine, hygromycin… Expand

A number of translation inhibitors were tested for their effects on both control and encephalomyocarditis virus-infected mouse… Expand

The antibiotic edenine induces binding of multiple 40 S ribosomes to reovirus messenger RNAs, producing complexes that sediment… Expand

Three lines of evidence are presented indicating that GTP hydrolysis associated with eukaryotic peptide initiation occurs in the… Expand

Edeine, a small basic peptide antibiotic, is shown to inhibit initiation of polyphenylalanine and globin peptides with little or… Expand

Abstract Some 30 compounds have been selected which inhibit polypeptide synthesis from aminoacyl tRNA in 70-S ribosomal systems… Expand