Edeine

Known as: Edeine [Chemical/Ingredient] 
Basic peptide antibiotic from Bacillus brevis. It exhibits broad-spectrum antibacterial activity and inhibits bacterial DNA synthesis.
National Institutes of Health

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10 relations

Broader (2)

Anti-Bacterial AgentsNucleic Acid Synthesis Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Narrower (1)

edeine A

Papers overview

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2006
2006
Structure activity relationship studies on the antimicrobial activity of novel edeine A and D analogues.
Edeines are pentapeptide amide antibiotics composed of four nonprotein amino acids, glycine, and polyamine. They exhibit… (More)
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Highly Cited
2004
Highly Cited
2004
Dissecting the ribosomal inhibition mechanisms of edeine and pactamycin: the universally conserved residues G693 and C795 regulate P-site RNA binding.
The crystal structures of the universal translation-initiation inhibitors edeine and pactamycin bound to ribosomal 30S subunit… (More)
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2001
2001
Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3.
The small ribosomal subunit is responsible for the decoding of genetic information and plays a key role in the initiation of… (More)
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Highly Cited
1987
Highly Cited
1987
Interaction of antibiotics with functional sites in 16S ribosomal RNA
Chemical footprinting shows that several classes of antibiotics (streptomycin, tetracycline, spectinomycin, edeine, hygromycin… (More)
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1983
1983
The antibiotic edeine. XII. Isolation and structure of edeine F.
The peptide antibiotic edeine F produced by Bacillus brevis Vm4, one of the components of edeine antibiotics complex, was… (More)
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Highly Cited
1978
Highly Cited
1978
Migration of 40 S ribosomal subunits on messenger RNA in the presence of edeine.
The antibiotic edenine induces binding of multiple 40 S ribosomes to reovirus messenger RNAs, producing complexes that sediment… (More)
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1978
1978
GTP hydrolysis during methionyl-tRNAf binding to 40 S ribosomal subunits and the site of edeine inhibition.
Three lines of evidence are presented indicating that GTP hydrolysis associated with eukaryotic peptide initiation occurs in the… (More)
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1976
1976
Inactive form of edeine in the edeine-producing Bacillus brevis Vm 4 cells.
1. Exogenous edeine inhibits the synthesis of DNA and protein, but not that of RNA, in extracts of edeine-producing Bacillus… (More)
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1974
1974
Edeine inhibition and resistance in Neurospora
To obtain data on the biochemical effects of edeine in the fungus Neurospora crassa, in vivo protein synthesis, in vitro protein… (More)
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1972
1972
The antibiotic edeine IX: The isolation and the composition of edeine D
Edein D wurde aus dem komplexen Antibioticum Edein mit Hilfe von Verteilungs-Chromatographie abgetrennt. Als Bausteine von Edein… (More)
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