EZN-2208

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2008-2014
02420082014

Papers overview

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2015
2015
PURPOSE Retinoic acid-arsenic trioxide (ATRA-ATO) combination therapy is the current standard of care for patients with acute… (More)
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2014
2014
BACKGROUND EZN-2208 is a water-soluble PEGylated conjugate of the topoisomerase inhibitor SN38, the active metabolite of… (More)
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2013
2013
Background Anti-angiogenic therapies such as bevacizumab upregulate hypoxia-inducible factor-1α (HIF-1α), a possible mechanism of… (More)
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2013
2013
This study evaluated the tolerability, pharmacokinetics, and preliminary antitumor activity of EZN-2208, a water-soluble poly… (More)
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2013
2013
BACKGROUND Irinotecan is cytotoxic in patients with advanced colorectal cancer (CRC). SN-38 (10-hydroxy-7-ethyl-camptothecin) is… (More)
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2012
2012
BRCA1 dysfunction in hereditary breast cancer causes defective homology-directed DNA repair and sensitivity towards DNA damaging… (More)
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2012
2012
BACKGROUND EZN-2208 is a water-soluble, polyethylene glycol drug conjugate of SN38, which is the active moiety of irinotecan. In… (More)
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2011
2011
Topoisomerase I inhibitors down-regulate HIF-1α leading to tumor growth inhibition, but only while maintaining sustained levels… (More)
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2010
2010
PURPOSE Treatment of neuroblastoma is successful in less than half of patients with high-risk disease. The antitumor activity of… (More)
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2009
2009
Examination of the clinical utility of SN38 (10-hydroxy-7-ethyl-camptothecin), the active metabolite of CPT-11, has not been… (More)
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