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EZN-2208

 
National Institutes of Health

Papers overview

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2014
2014
BACKGROUND EZN-2208 is a water-soluble PEGylated conjugate of the topoisomerase inhibitor SN38, the active metabolite of… Expand
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2013
2013
PurposeThis study evaluated the tolerability, pharmacokinetics, and preliminary antitumor activity of EZN-2208, a water-soluble… Expand
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2013
2013
BACKGROUND Irinotecan is cytotoxic in patients with advanced colorectal cancer (CRC). SN-38 (10-hydroxy-7-ethyl-camptothecin) is… Expand
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2013
2013
SummaryBackground Anti-angiogenic therapies such as bevacizumab upregulate hypoxia-inducible factor-1α (HIF-1α), a possible… Expand
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2012
2012
BACKGROUND EZN-2208 is a water-soluble, polyethylene glycol drug conjugate of SN38, which is the active moiety of irinotecan. In… Expand
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2012
2012
BRCA1 dysfunction in hereditary breast cancer causes defective homology-directed DNA repair and sensitivity towards DNA damaging… Expand
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2011
2011
Topoisomerase I inhibitors down-regulate HIF-1α leading to tumor growth inhibition, but only while maintaining sustained levels… Expand
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2010
2010
Purpose: Treatment of neuroblastoma is successful in less than half of patients with high-risk disease. The antitumor activity of… Expand
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2009
2009
Examination of the clinical utility of SN38 (10-hydroxy-7-ethyl-camptothecin), the active metabolite of CPT-11, has not been… Expand
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Highly Cited
2008
Highly Cited
2008
Purpose: Clinical development of SN38, the active metabolite of camptothecin-11 (CPT-11), has been hampered due to its poor… Expand
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