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EWSR1/FLI1 Fusion Gene

Known as: FLI1/EWS FUSION GENE, EWS/FLI1 Fusion Gene, EWSR1-FLI1 Fusion Gene 
A fusion gene that results from a chromosomal translocation t(11;22)(q24;q12) which fuses the first seven or ten exons of the EWSR1 gene with exon 5… 
National Institutes of Health

Related topics

Related topics

17 relations
Askin's tumorEWS-FLI1 fusion proteinEwing Sarcoma of BoneEwing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Abstract 2028: Transcriptional modules involving EWS-FLI1 and SRF in Ewing sarcoma
Ewing Sarcoma (ES) is an aggressive pediatric bone tumor with a high tendency to metastasize. The primary genetic aberration… 
Highly Cited
2016
Highly Cited
2016
Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model
Ewing sarcoma (ES) involves a tumor-specific chromosomal translocation that produces the EWS-FLI1 protein, which is required for… 
2015
2015
Factor V: an active player in inflammation.
In this issue of Blood , [Liang et al][1] identify a critical role of coagulation factor V in host inflammation response to… 
2015
2015
The Influence of FLI1 Expression Levels on Megakaryopoiesis: Studies Using iPSCs
Jacobsen syndrome is a rare, inherited hemizygous deletion of chromosome 11q that is often associated with a dysmegakaryopoiesis… 
2014
2014
Abstract LB-197: YK-4-279 is effective in treating EWS-FLI1 induced myeloid/erythroid leukemia in a transgenic mouse model
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Ewing sarcoma is an aggressive neoplasm affecting bone and… 
2008
2008
Neural differentiation arrest in embryonal carcinoma cells with forced expression of EWS-FLI1
Ewing’s sarcoma/primitive neuroectodermal tumor (EWS/PNET) has a characteristic chimeric oncogene EWS-FLI1, which results from… 
Review
2003
Review
2003
Potentials for RNAi in sarcoma research and therapy: Ewing's sarcoma as a model.
2003
2003
Diagnostic significance and clinical applications of chimeric genes in Ewing's sarcoma.
Ewing's sarcoma (ES) is one of the most malignant bone and soft tissue tumors in childhood. Morphologically, ES belongs to the… 
Highly Cited
1999
Highly Cited
1999
Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein
Chromosomal translocations resulting in the expression of chimaeric transcription factors are frequently observed in tumour cells… 
Highly Cited
1999
Highly Cited
1999
Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein
Nature Genet. 23, 222–227 (1999). In the abstract, "ES cells" were indicated to be embryonic stem cells, when in fact they were… 
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