EWS-FLI1 fusion protein

Known as: EWS/FLI1 Fusion Protein, EWS-FLI-1, EWSR1/FLI1 Fusion Protein 
A fusion protein encoded by the EWSR1/FLI1 fusion gene. This protein is comprised of the transactivation domain of the RNA-binding protein EWS fused… (More)
National Institutes of Health

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2015
2015
The synthesis and processing of mRNA, from transcription to translation initiation, often requires splicing of intragenic… (More)
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2015
2015
Transcription factor fusion proteins can transform cells by inducing global changes of the transcriptome, often creating a state… (More)
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Highly Cited
2010
Highly Cited
2010
Cancer stem cells (CSCs) display plasticity and self-renewal properties reminiscent of normal tissue stem cells, but the events… (More)
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Highly Cited
2009
Highly Cited
2009
Ewing sarcoma family of tumors (ESFT) is an undifferentiated neoplasm of the bone and soft tissue. ESFT is characterized by a… (More)
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Highly Cited
2003
Highly Cited
2003
Translocation t(11;22) is a karyotypic abnormality detected in over 90% of Ewing's family tumors. This translocation results in… (More)
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Highly Cited
1999
Highly Cited
1999
Chromosomal translocations resulting in the expression of chimaeric transcription factors are frequently observed in tumour cells… (More)
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1999
1999
PURPOSE There are a variety of solid tumors in which alternative chromosomal translocations generate related fusion products. In… (More)
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Highly Cited
1998
Highly Cited
1998
PURPOSE More than 90% of Ewing's sarcomas (ES) contain a fusion of the EWS and FLI1 genes, due to the t(11;22)(q24;q12… (More)
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Highly Cited
1995
Highly Cited
1995
Most Ewing's sarcomas or related primitive neuroectodermal tumors have the (11;22)(q24;q12) or less frequently the (21;22)(q22… (More)
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Highly Cited
1994
Highly Cited
1994
The 5' half of the EWS gene has recently been described to be fused to the 3' regions of genes encoding the DNA-binding domain of… (More)
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