FAQ

ERRFI1 wt Allele

Known as: Mitogen-Inducible Gene 6, Receptor-Associated Late Transducer Gene, RALT 
Human ERRFI1 wild-type allele is located in the vicinity of 1p36 and is approximately 22 kb in length. This allele, which encodes ERBB receptor… (More)

Topic mentions per year

Topic mentions per year

2000-2017
02420002017

Related topics

Related topics

7 relations
1p36Cellular Stress ResponseSignal TransductionSignal Transduction Inhibition
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Broader (1)

ERRFI1 gene

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
ERRFI1 wt Allele
Signal Transduction
lung development
keratinocyte differentiation
1p36
Cellular Stress Response

Papers overview

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2014
2014
microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastoma.
Great interest persists in useful prognostic and therapeutic targets in glioblastoma. In this study, we report the definition of… (More)
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2014
2014
The TGFβ-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors.
Although specific mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) identify tumors that are… (More)
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2013
2013
Regulation of EGFR trafficking and cell signaling by Sprouty2 and MIG6 in lung cancer cells.
The duration and specificity of epidermal growth factor receptor (EGFR) activation and signaling are determinants of cellular… (More)
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2010
2010
A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation
Signaling by epidermal growth factor receptor (EGFR) must be controlled tightly because aberrant EGFR activity may cause cell… (More)
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2009
2009
Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.
ACK1 (activated Cdc42-associated kinase 1), a cytoplsmic tyrosine kinase, is implicated in metastatic behavior, cell spreading… (More)
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2009
2009
Mutation of epidermal growth factor receptor is associated with MIG6 expression.
Controlled activation of epidermal growth factor receptor (EGFR) is systematically guaranteed at the molecular level; however… (More)
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Highly Cited
2007
Highly Cited
2007
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Members of the epidermal growth factor receptor family (EGFR/ERBB1, ERBB2/HER2, ERBB3/HER3 and ERBB4/HER4) are key targets for… (More)
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2005
2005
Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin
An emerging paradigm holds that loss of negative signalling to receptor tyrosine kinases (RTKs) is permissive for their oncogenic… (More)
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2003
2003
Feedback inhibition by RALT controls signal output by the ErbB network
The ErbB-2 interacting protein receptor-associated late transducer (RALT) was previously identified as a feedback inhibitor of… (More)
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2002
2002
Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control
Over-expression studies have demonstrated that RALT (receptor associated late transducer) is a feedback inhibitor of ErbB-2… (More)
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