ERN1 wt Allele

Known as: IRE1a, IRE1P, Endoplasmic Reticulum To Nucleus Signaling 1 wt Allele 
Human ERN1 wild-type allele is located in the vicinity of 17q24.2 and is approximately 88 kb in length. This allele, which encodes serine/threonine… (More)
National Institutes of Health

Papers overview

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2015
2015
An accumulation of misfolded proteins in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR) mediated via… (More)
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Highly Cited
2012
Highly Cited
2012
Endoplasmic reticulum (ER)-mediated protein secretion and quality control have been shown to play an important role in immune… (More)
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2012
2012
Huntington's disease (HD), an inherited neurodegenerative disorder, is caused by an expansion of cytosine-adenine-guanine repeats… (More)
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2012
2012
The endoplasmic reticulum (ER) stress sensor, IRE1, contains a kinase domain and a ribonuclease domain. Ribonuclease mediates the… (More)
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Highly Cited
2011
Highly Cited
2011
IRE1 plays an essential role in the endoplasmic reticulum (ER) stress response in yeast and mammals. We found that a double… (More)
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Highly Cited
2010
Highly Cited
2010
Accumulation of misfolded proteins in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), an… (More)
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Highly Cited
2007
Highly Cited
2007
Endoplasmic reticulum (ER) stress activates a set of signaling pathways, collectively termed the unfolded protein response (UPR… (More)
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Highly Cited
2006
Highly Cited
2006
In pancreatic beta cells, the endoplasmic reticulum (ER) is an important site for insulin biosynthesis and the folding of newly… (More)
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Highly Cited
2000
Highly Cited
2000
Malfolded proteins in the endoplasmic reticulum (ER) induce cellular stress and activate c-Jun amino-terminal kinases (JNKs or… (More)
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Highly Cited
1998
Highly Cited
1998
When unfolded proteins accumulate in the endoplasmic reticulum (ER), transcription of glucose-regulated proteins (GRPs… (More)
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