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ERK1 and ERK2 cascade

Known as: ERK1/2 cascade, extracellular signal-regulated kinase 1/2 cascade, ERK1 and ERK2 signalling pathway 
An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two… 
National Institutes of Health

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Broader (1)

ERK cascade
negative regulation of ERK1 and ERK2 cascadepositive regulation of ERK1 and ERK2 cascade

Papers overview

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2015
2015
Tenascin-C induces resistance to apoptosis in pancreatic cancer cell through activation of ERK/NF-κB pathway
As a glycol-protein located in extracellular matrix (ECM), tenascin-C (TNC) is absent in most normal adult tissues but is highly… 
2014
2014
Abstract 13847: PTRF/Cavin-1 Knock-out Mice Develop a Progressive Cardiomyopathy with ERK1/2 Hyperactivation and Caveolin-3 Reduction
Background: Mutations in the PTRF gene, coding for Cavin-1, cause congenital generalized lipodystrophy type 4 (CGL4) associated… 
2014
2014
[Inhibitory effect of taurine in hypoxia-induced rat pulmonary artery smooth muscle cell proliferation and signal transduction mechanism].
OBJECTIVE To discuss the effect of taurine (Tau) on the proliferation of hypoxia-induced pulmonary artery smooth muscle cells… 
2012
2012
Increased sensitivity to alcohol induced changes in ERK Map kinase phosphorylation and memory disruption in adolescent as compared to adult C57BL/6J mice
2009
2009
Phosphorylized ERK1/2 is upregulated in diabetic rats after global cerebral ischemia-reperfusion injury
Objective To explore the expression of extracellular signal-regulated kinase 1/2 (ERK1/2) in the hippocampus CA4 region of… 
2008
2008
[PKCalpha-ERK1/2 cascade is involved in up-regulation of cyclinD1 and P21(cip1) in human airway smooth muscle cells sensitized by sera from atopic asthmatics].
OBJECTIVE To explore the role of PKCalpha-ERK1/2 cascade in PMA induced up-regulation of cyclinD1 and P21(cip1) in human airway… 
Highly Cited
2006
Highly Cited
2006
A delayed gonadotropin-dependent and growth factor-mediated activation of the extracellular signal-regulated kinase 1/2 cascade negatively regulates aromatase expression in granulosa cells.
Human chorionic gonadotropin and human FSH (hFSH) elicit a transient increase in ERK1/2 phosphorylation lasting less than 60 min… 
2006
2006
Antisense ERK1/2 oligodeoxynucleotide gene therapy attenuates graft arteriosclerosis of aortic transplant in a rat model.
2005
2005
Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative.
2002
2002
[Role of suppressor encoprotein PTEN in IGF-1 induced activation of ERK in endometrial carcinoma cells].
BACKGROUND & OBJECTIVES The machanism of signal transduction of insulin-like growth factor (IGF-1) in endometrial carcinoma is… 
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