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EPAS1 wt Allele

Known as: PASD2, ECYT4, Endothelial PAS Domain Protein 1 wt Allele 
Human EPAS1 wild-type allele is located within 2p21-p16 and is approximately 93 kb in length. This allele, which encodes endothelial PAS domain… 
National Institutes of Health

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Cellular Stress ResponseHomo sapiensTranscriptional Regulationdna binding

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endothelial PAS domain protein 1, human

Papers overview

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2018
2018
HIF 1 a and HIF 2 a independently activate SRC to promote melanoma metastases
Malignant melanoma is characterized by a propensity for early lymphatic and hematogenous spread. The hypoxia-inducible factor… 
2017
2017
Targeting HIF 2 in Clear Cell Renal Cell Carcinoma
Inactivation of the von Hippel–Lindau tumor-suppressor protein (pVHL) is the signature “truncal” event in clear cell renal cell… 
2015
2015
HIF inhibition in metastatic renal cell carcinoma (mRCC): Final results of a phase Ib /IIa clinical trial evaluating the nanoparticle drug conjugate (NDC), CRLX101, in combination with bevacizumab…
4543 Background: VHL inactivation occurs in most clear cell RCCs and results in expression of the HIF hypoxia response program… 
2014
2014
Examining the Polymorphisms in the Hypoxia Pathway Genes in Relation to Outcome in Colorectal Cancer
Introduction Colorectal cancer is a common malignancy. Identification of genetic prognostic markers may help prognostic… 
2014
2014
Abstract 19: Novel HIF2A mutations disrupting oxygen sensing lead to a new syndrome of multiple paragangliomas and somatostatinomas associated with polycythemia
Hypoxia inducible factors (HIFs) control the cellular response to hypoxia and when dysregulated, contribute to tumorigenesis. We… 
2014
2014
Chromatin , Gene , and RNA Regulation Prognostic Potential of DNA Methylation and Transcript Levels of HIF 1 A and EPAS 1 in Colorectal Cancer
Hypoxic conditions during the formation of colorectal cancer may support the development of more aggressive tumors. Hypoxia… 
Review
2011
Review
2011
[Transcriptional regulation of osteoarthritis].
Osteoarthritis (OA) is one of the most common skeletal disorders characterized by cartilage degradation ; however, little was… 
2010
2010
Hypoxia: The HIF2α puzzle
Two studies describe different roles for HIF2α in cancer. It can promote tumorigenesis by mediating the infiltration of tumour… 
2006
2006
Tumor VEGFA gene expression is associated with serum lactate dehydrogenase (LDH) levels and intratumoral mRNA expression of genes involved in glycolysis in patients with metastatic colorectal cancer…
3530 Background: It is well known that angiogenesis and glycolysis are regulated by hypoxic conditions. Recent clinical trials… 
1998
1998
Gene expression pattern Expression of ARNT, ARNT2, HIF1a, HIF2a and Ah receptor mRNAs in the developing mouse
The basic helix-loop-helix-PAS (bHLH-PAS) protein ARNT is a dimeric partner of the Ah receptor (AHR) and hypoxia inducible factor… 
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