EPAS1 wt Allele

Known as: PASD2, ECYT4, Endothelial PAS Domain Protein 1 wt Allele 
Human EPAS1 wild-type allele is located within 2p21-p16 and is approximately 93 kb in length. This allele, which encodes endothelial PAS domain… (More)
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
PURPOSE The occurrence of ≥ two distinct types of tumors, one of them paraganglioma (PGL), is unusual in an individual patient… (More)
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Highly Cited
2012
Highly Cited
2012
Hypoxia-inducible factors are transcription factors controlling energy, iron metabolism, erythropoiesis, and development. When… (More)
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Review
2010
Review
2010
Oxygen (O(2)) is an essential nutrient that serves as a key substrate in cellular metabolism and bioenergetics. In a variety of… (More)
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Highly Cited
2010
Highly Cited
2010
Human embryonic stem (hES) cells are routinely cultured under atmospheric, 20% oxygen tensions but are derived from embryos which… (More)
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Highly Cited
2009
Highly Cited
2009
Glioblastomas are lethal cancers characterized by florid angiogenesis promoted in part by glioma stem cells (GSCs). Because… (More)
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Highly Cited
2009
Highly Cited
2009
HIF transcription factors (HIF-1 and HIF-2) are central mediators of cellular adaptation to hypoxia. Because the resting partial… (More)
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Highly Cited
2003
Highly Cited
2003
Organ-specific metastasis is governed, in part, by interactions between chemokine receptors on cancer cells and matching… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE Hypoxia-inducible factors HIF1alpha and HIF2alpha (HIFalphas) regulate the expression of a variety of genes encoding… (More)
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Highly Cited
2001
Highly Cited
2001
Carbonic anhydrase-9 (CA9), a transmembrane enzyme with an extracellular active site, is involved in the reversible metabolism of… (More)
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Highly Cited
1997
Highly Cited
1997
In an effort to better understand the mechanism of toxicity of 2,3,7, 8-tetrachlorodibenzo-p-dioxin, we employed an iterative… (More)
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