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EPAS1 wt Allele

Known as: PASD2, ECYT4, Endothelial PAS Domain Protein 1 wt Allele 
Human EPAS1 wild-type allele is located within 2p21-p16 and is approximately 93 kb in length. This allele, which encodes endothelial PAS domain… 
National Institutes of Health

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Cellular Stress ResponseHomo sapiensTranscriptional Regulationdna binding

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endothelial PAS domain protein 1, human

Papers overview

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2020
2020
Effects and Mechanism of Action of PX-478 in Oxygen-Induced Retinopathy in Mice
Importance: Retinopathy of prematurity (ROP) is an important risk factor for blindness in children due to neovascularization (NV… 
2018
2018
HIF 1 a and HIF 2 a independently activate SRC to promote melanoma metastases
Malignant melanoma is characterized by a propensity for early lymphatic and hematogenous spread. The hypoxia-inducible factor… 
2017
2017
Targeting HIF 2 in Clear Cell Renal Cell Carcinoma
Inactivation of the von Hippel–Lindau tumor-suppressor protein (pVHL) is the signature “truncal” event in clear cell renal cell… 
2016
2016
Vhl deletion in renal epithelia causes HIF-1α-dependent, HIF-2α-independent angiogenesis and constitutive diuresis
One of the earliest requirements for the formation of a solid tumor is the establishment of an adequate blood supply. Clear cell… 
2016
2016
Reduced Perinatal Leptin Availability May Contribute to Adverse Metabolic Programming in a Rat Model of Uteroplacental Insufficiency.
Leptin availability in perinatal life critically affects metabolic programming. We tested the hypothesis that uteroplacental… 
2014
2014
Examining the Polymorphisms in the Hypoxia Pathway Genes in Relation to Outcome in Colorectal Cancer
Introduction Colorectal cancer is a common malignancy. Identification of genetic prognostic markers may help prognostic… 
Highly Cited
2013
Highly Cited
2013
HIF2A and IGF2 expression correlates in human neuroblastoma cells and normal immature sympathetic neuroblasts.
During normal sympathetic nervous system (SNS) development, cells of the ganglionic lineage can malignantly transform and develop… 
2011
2011
Hypoxia: HIF switch
The switch from HIF1α-dependent to HIF2α-dependent responses may be partly mediated through the ubiquitin ligase HAF, leading to… 
2006
2006
Tumor VEGFA gene expression is associated with serum lactate dehydrogenase (LDH) levels and intratumoral mRNA expression of genes involved in glycolysis in patients with metastatic colorectal cancer…
3530 Background: It is well known that angiogenesis and glycolysis are regulated by hypoxic conditions. Recent clinical trials… 
1998
1998
Gene expression pattern Expression of ARNT, ARNT2, HIF1a, HIF2a and Ah receptor mRNAs in the developing mouse
The basic helix-loop-helix-PAS (bHLH-PAS) protein ARNT is a dimeric partner of the Ah receptor (AHR) and hypoxia inducible factor… 
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