endothelial PAS domain protein 1, human

Known as: Class E Basic Helix-Loop-Helix Protein 73, Hypoxia-Inducible Factor 2-Alpha, HIF-1alpha-Like Factor 
Endothelial PAS domain-containing protein 1 (870 aa, ~96 kDa) is encoded by the human EPAS1 gene. This protein plays a role in both the response to… (More)
National Institutes of Health

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Topic mentions per year

1947-2018
05010015019472017

Papers overview

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2013
2013
BACKGROUND & AIMS Hypoxic inflammation (decreased oxygen tension at sites of inflammation) is a feature of inflammatory bowel… (More)
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Highly Cited
2007
Highly Cited
2007
Hypoxia stimulates erythropoiesis, the major iron-utilization pathway. We report the discovery of a conserved, functional iron… (More)
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2004
2004
Endothelial PAS domain protein 1 (EPAS1) is a basic-helix-loop-helix/PAS domain transcription factor that is expressed… (More)
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Highly Cited
2004
Highly Cited
2004
Activation of the hypoxia-inducible factor alpha-subunits, HIF-1alpha and HIF-2alpha, seems to be subject to similar regulatory… (More)
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2002
2002
Hypoxia is a potent inducer of tumor angiogenesis, the process of which is mostly mediated by induction of vascular endothelial… (More)
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Highly Cited
2000
Highly Cited
2000
We have studied the role of the basic helix-loop-helix-PAS transcription factor EPAS-1/hypoxia-inducible factor 2alpha in… (More)
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Highly Cited
1998
Highly Cited
1998
Hypoxia results in adaptive changes in the transcription of a range of genes including erythropoietin. An important mediator is… (More)
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Highly Cited
1998
Highly Cited
1998
Mice lacking the hypoxia-inducible transcription factor EPAS1 die at mid-gestation. Despite normal morphological development of… (More)
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1998
1998
Hypoxia results in adaptive changes in the transcription of a range of genes including erythropoietin. An important mediator is… (More)
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Highly Cited
1997
Highly Cited
1997
Here we describe the cloning and characterization of a PAS domain transcription factor termed endothelial PAS-1 (EPAS1). This… (More)
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