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This paper reports on the modification of two synthetic steps in the usual protocol used for obtaining EMICORON. EMICORON is a… Expand BACKGROUND
During the last decade, guanine G-rich sequences folding into G-quadruplex (G4) structures have received a lot of… Expand A novel approach to cancer therapeutics is emerging in the field of G-quadruplex (G4) ligands, small molecules designed to… Expand Background. G-quadruplex (G4) structures, present at the telomeric ends of chromosomes and in the promoters of a wide range of… Expand We previously identified EMICORON as a novel G-quadruplex (G4) ligand showing high selectivity for G4 structures over the duplex… Expand Based on previous work on both perylene and coronene derivatives as G‐quadruplex binders, a novel chimeric compound was designed… Expand