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EMICORON

National Institutes of Health

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2 relations

Broader (2)

ImidesPiperidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
New Developments in the Synthesis of EMICORON
This paper reports on the modification of two synthetic steps in the usual protocol used for obtaining EMICORON. EMICORON is a… Expand
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Review
2017
Review
2017
EMICORON: A multi-targeting G4 ligand with a promising preclinical profile.
BACKGROUND During the last decade, guanine G-rich sequences folding into G-quadruplex (G4) structures have received a lot of… Expand
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2016
2016
Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells.
A novel approach to cancer therapeutics is emerging in the field of G-quadruplex (G4) ligands, small molecules designed to… Expand
2016
2016
Abstract 266: The G-quadruplex ligand EMICORON potentiates the antitumor efficacy of chemotherapy on colon cancer experimental models
Background. G-quadruplex (G4) structures, present at the telomeric ends of chromosomes and in the promoters of a wide range of… Expand
2015
2015
Targeting G-Quadruplex DNA Structures by EMICORON Has a Strong Antitumor Efficacy against Advanced Models of Human Colon Cancer
We previously identified EMICORON as a novel G-quadruplex (G4) ligand showing high selectivity for G4 structures over the duplex… Expand
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2012
2012
Aromatic Core Extension in the Series of N‐Cyclic Bay‐Substituted Perylene G‐Quadruplex Ligands: Increased Telomere Damage, Antitumor Activity, and Strong Selectivity for Neoplastic over Healthy…
Based on previous work on both perylene and coronene derivatives as G‐quadruplex binders, a novel chimeric compound was designed… Expand
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